The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
MICROBIAL TRANSFORMATION OF IMMUNOSUPPRESSIVE COMPOUNDS
I. DESMETHYLATION OF FK506 AND IMMUNOMYCIN (FR 900520) BY Actinoplanes sp. ATCC 53771
TOM S. CHEN, BYRON H. ARISON, LINDA S. WICKER, EDWARD S. INAMINE, RICHARD L. MONAGHAN
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1992 Volume 45 Issue 1 Pages 118-123

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Abstract

The immimosuppressants FK506 and FR 900520 were desmethylated by Actinoplanes sp. ATCC 53771 to yield various O-desmethylated products. The products were isolated and purified by solvent extraction and HPLC chromatography, and identified by NMR and MS spectroscopy.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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