A NOVEL QUINONE ANTIBIOTIC FROM Malbranchea cinnamomea TAIM 13T54

YIN-MEI CHIUNG; TOMOYUKI FUJITA; MASAHIRA NAKAGAWA; HIROSHI NOZAKI; GUEH-YUH CHEN; ZUEI-CHING CHEN; MITSURU NAKAYAMA

doi:10.7164/antibiotics.46.1819

A NOVEL QUINONE ANTIBIOTIC FROM Malbranchea cinnamomea TAIM 13T54

YIN-MEI CHIUNG, TOMOYUKI FUJITA, MASAHIRA NAKAGAWA, HIROSHI NOZAKI, GUEH-YUH CHEN, ZUEI-CHING CHEN, MITSURU NAKAYAMA

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JOURNAL FREE ACCESS

1993 Volume 46 Issue 12 Pages 1819-1826

DOI https://doi.org/10.7164/antibiotics.46.1819

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Abstract

A novel quinone antibiotic named malbranicin was isolated from the culture filtrate and mycelium of Malbranchea cinnamomea TAIM 13T54, a thermophilic fungus. The antibiotic was elucidated to be 6-(1-acetylethyl)-2-methoxy-2, 5-cyclohexadiene-1, 4-dione by spectral analysis. Malbranicin exhibited antimicrobial and cytotoxic activities against Gram-positive bacteria and mammalian cell lines, respectively.

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