Isochromophilones III - VI, Inhibitors of Acyl-CoA: Cholesterol Acyltransferase Produced by Penicillium multicolor FO-3216

NORIKO ARAI; KAZURO SHIOMI; HIROSHI TOMODA; NORIKO TABATA; DA JUN YANG; ROKURO MASUMA; TOMOYA KAWAKUBO; SATOSHI OMURA

doi:10.7164/antibiotics.48.696

Isochromophilones III - VI, Inhibitors of Acyl-CoA: Cholesterol Acyltransferase Produced by Penicillium multicolor FO-3216

NORIKO ARAI, KAZURO SHIOMI, HIROSHI TOMODA, NORIKO TABATA, DA JUN YANG, ROKURO MASUMA, TOMOYA KAWAKUBO, SATOSHI OMURA

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JOURNAL FREE ACCESS

1995 Volume 48 Issue 7 Pages 696-702

DOI https://doi.org/10.7164/antibiotics.48.696

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Abstract

New azaphilones named isochromophilones III-VI were isolated from the culture broth of Penicillium multicolor FO-3216 as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT). Their structures were elucidated by NMR and other spectroscopic analyses. The IC₅₀ values of isochromophilones III, IV, V and VI for ACAT activity in an enzyme assay using rat liver microsomes were calculated to be 110, 50, 50 and 120μM, respectively.

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