口唇,口蓋裂発生に関する実験的研究 第7報:A/J系マウスにおける自然発現口唇,口蓋裂に対するestradiolの示す抑制作用について

三浦 茂樹; 夏目 長門; 堀内 隆作; 中村 友保; 加納 欣徳; 藤原 浩; 古川 博雄; 稲垣 鐘司; 生川 哲也; 河合 幹

doi:10.11224/cleftpalate1976.15.2_116

Experimental Study on Cleft Lip and Palate

Reduction of Spontaneous Cleft Lip and Palate related with Prolonged Estrous Cycle in aged A/J strain mice

Shigeki MIURA, Nagato NATSUME, Shuichi SUGIMOTO, Ryusaku HORIUCHI, Tomoyasu NAKAMURA, Yoshinori KANOH, Hiroshi FUJIWARA, Shoji INAGAKI, Tetsuya NARUKAWA, Tsuyoshi KAWAI

Author information

Shigeki MIURA
The Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University
Nagato NATSUME
The Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University
Shuichi SUGIMOTO
The Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University
Ryusaku HORIUCHI
The Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University
Tomoyasu NAKAMURA
The Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University
Yoshinori KANOH
The Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University
Hiroshi FUJIWARA
The Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University
Shoji INAGAKI
The Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University
Tetsuya NARUKAWA
The Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University
Tsuyoshi KAWAI
The Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University

Keywords: A/J strain mice, cleft lip and palate, aging, estradiol, prolonged estrous cycle

JOURNAL FREE ACCESS

1990 Volume 15 Issue 2 Pages 116-121

DOI https://doi.org/10.11224/cleftpalate1976.15.2_116

J-STAGE : cleftpalate1976 15 3 pp.e1a

Details

Abstract

This study was performed to identify various factors influencing the incidence of cleft lip and palate in aged (more than 280 days) A/J strain mice. These factors included estrous cycle, maternal weight, implantation site, prenatal mortality, and litter size.
1. The incidence of cleft palate with cleft lip was 5.5±11.0 % and that of cleft palate without cleft lip was 1.8±7.5 %.
2. The reduction of cleft lip and palate was significantly related to the prolonged estrous cycle.
3. The results were discussed in relation to the reduction of cleft lip and palate with estradiol in A/J strain mice.

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