A Case of Genital Paget’s Carcinoma with Multiple Bone Metastasis that Responded to Weekly PET (Cisplatin-Epirubicin-Paclitaxel) Therapy

Abstract

We report a case of genital Paget’s carcinoma with multiple bone metastasis that responded to combination chemotherapy. The patient is a 64-year-old male. He visited our hospital in October of 2000. Palm-size erythema with nodules was present on the right side of his scrotum. The erythematous lesion, right inguinal and common iliac lymph nodes were resected in December of 2000. We also perfomed some adjuvant chemotherapy. Two years after tumor removal, multiple bone metastases with hypercalcemia were recognized. Therefore, he underwent weekly PET therapy [Cisplatin: 30mg/m² , epirubicin: 50 mg/m², Paclitaxel: 120 mg/m² (day1), G-CSF: 300 μg (day 3–5)]. The metastatic tumors were responded well to the therapy ; their size was reduced by computed tomography, and his serum levels of CEA and calcium were normalized.