1977-2010 Clinical Study of Maxillary Sinus Carcinoma

Abstract

We retrospectively analyzed long-term efficacy of multimodality therapy in 142 subjects with advanced maxillary sinus carcinoma between 1977 and 2010. Combined multimodality therapy based on Sato’s method consisted of intraarterial chemotherapy combined with radiotherapy and organ preservation surgery from 1977 to 1995, but results in 82 cases were unsatisfactory in T3 and T4 cases. To improve local control and survival, we refined combined therapy with weekly intraarterial carboplatin infusion combined with radiotherapy and radical extended surgery in 24 cases, raising cumulative cause-specific 5-year-survival rate to 100% in T3 and 56.7% in T4. Organ preservation decreased from that of combined multimodality therapy. To improve local control, survival and organ preservation in T4, we conducted superselective intraarterial cisplatin infusion combined with radiotherapy and organ preservation surgery in 36 cases, raising cumulative cause-specific 5-year-survival to 100% in T3 and 81.6% in T4. High organ preservation was also possible with all cases preserving ocular function. In conclusion, superselective intraarterial CDDP infusion combined with radiotherapy and organ preservation surgery is highly effective in treating advanced maxillary sinus carcinomas and improves prognosis and organ preservation.