Basic Forefront Research in the Field of Nephrology

Abstract

We have worked to develop new diagnostic and therapeutic tools based on experimental proof-of-concept obtained through the analysis of pathological mechanisms underlying kidney diseases. For this purpose, for the first time in Japan, we introduced multiphoton laser microscopy with an in vivo bio-imaging system that revealed physiological functions of the kidney and various pathological mechanisms. We used these findings to develop new therapeutic means and biomarkers. In addition, we successfully established erythropoietin-producing cells from human iPS cells as a new therapeutic tool for renal anemia. Further development of erythropoietin-related drugs is expected in the future. We believe that these cells represent the only tool to help obtain proof-of-concept for mechanisms of action of such drugs. Here we discuss these kidney-related, multifaceted basic studies.