Development of porous type anion exchange resin for purpose of removal of bilirubin

Abstract

We developed of a new porous type anion exchange resin (DIAION) for removal of bilirubin. In present study, in vitro adsorption of bilirubin was tested with this material. In vivo studies were performed to investigate its adsorptive capacities for bilirubin in connection with direct hemoperfusion (DHP) and plasmapheresis using jaundiced dogs. As results of in vitro and vivo tests, adsorbability of its material for bilirubin was about 5mg/gDIAION. It was concluded that the porous type anion exchange resin had selective adsorbability for bilirubin and had to effect in high hyperbilirubinemia.