Efficacy of Nafamostat mesilate as a regional anticoagulant on clinical plasma exchange in the patient with bleeding

Abstract

A total of 175 plasma exchange (PE) using Nafamostat mesilate (FUT) anticoagulation were accomplished in 21 patients with bleeding tendency or active bleeding. PE was safely performed in all cases. There was no worsening of bleedig or bleeding tendency during and after PE. Moreover, bleeding ceased during PE in 6 cases. Celite-clotting time was not prolonged during PE in systemic blood. APTT was only prolonged in the extracorporeal circuit but in sysytemic blood. FUT anticoagulation makes it safer to perform PE in the patient with bleeding or bleeding tendency.