ヤギ胎仔子宮外保育システムの開発 ―臍帯動静脈を用いたA-V ECMOの検討―

海野 信也; 長屋 憲; 篠塚 憲男; 桑原 慶紀; 岡井 崇; 上妻 志郎; 前田 津紀夫; 水野 正彦; 桑名 克之

doi:10.11392/jsao1972.17.1268

DEVELOPMENT OF EXTRAUTERINE FETAL INCUBATION SYSTEM

-A study of fetal A-V ECMO-

N UNNO, K NAGAYA, N SHINOZUKA, Y KUWABARA, T OKAI, S KOUZUMA, T MAEDA, M MIZUNO, K. KUWANA

Author information

N UNNO
Department of Obstetrics and Gynecology, Faculty of medicine, Univ. Tokyo
K NAGAYA
Department of Obstetrics and Gynecology, Faculty of medicine, Univ. Tokyo
N SHINOZUKA
Department of Obstetrics and Gynecology, Faculty of medicine, Univ. Tokyo
Y KUWABARA
Department of Obstetrics and Gynecology, Faculty of medicine, Univ. Tokyo
T OKAI
Department of Obstetrics and Gynecology, Faculty of medicine, Univ. Tokyo
S KOUZUMA
Department of Obstetrics and Gynecology, Faculty of medicine, Univ. Tokyo
T MAEDA
Department of Obstetrics and Gynecology, Faculty of medicine, Univ. Tokyo
M MIZUNO
Department of Obstetrics and Gynecology, Faculty of medicine, Univ. Tokyo
K. KUWANA
Senko Med. Trading Go.

Keywords: Artificial uterus, Artificial placenta, Extrauterine fetus, A—V ECMO

JOURNAL FREE ACCESS

1988 Volume 17 Issue 3 Pages 1268-1274

DOI https://doi.org/10.11392/jsao1972.17.1268

Details

Abstract

A study was undertaken to investigate the applicability of the arte riovenous ECMO via umbilical vessels for “Artificial Uterus”, which would be designed to incubate the fetus in the environment simulating in-utero conditions. 42 goat fetuses were incubated in the artificial amniotic fluid container. The oxygenation was totally sustained by A—V ECMO using the silicone hollow fiber membrane oxygenator. In the improved system, the average of incubation period was 146 hours, and the longest was 236 hours. Active fetal movements were demonstrated during incubation. The results suggest that fetal A—V ECMO will be useful for the study of fetal physiology and the management of ill fetuses in near future.

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