Abstract
The case is a 2 years 3 months old female. She was complaining of fever, lethargy, left hemiplegia and convulsion in the tongue. By laboratory examinations, the pressure of the cerebrospinal fluid was 200 mmH2O, cell count 429/3, sugar 75 mg/dl, Pandy negative and Nonne-Appelt nagative. In the blood picture, leucocytosis of moderate degree was noted. The case died with the manifestation of difficult deglutition and tristnus. A strain of virus identified with herpes simplex virus was isolated from the brain after autopsy.
Follpwing the reports by Reames (1941), Zaraf onetis (1944), Whitman (1946), Fischer (1947) and others, the case is the 6 th well founded case of primary herpetic meningoencephalitis to be recorded in the literature. Changes found in the brain were demyelinization foci of various sizes, perivascular looseness, degeneration of the nerve cells, residual nodules, diffuse proliferation of glia cells, localized gatherings of glia cells, perivascular cell infiltrations and intramuclear inclusion bodies. They are summarized as follows.
1) The distribution of these changes is diffuse.
2) The character of the changes is primarily degenerative, and the cellular reaction is mild.
3) So-called A-type inclusion bodies are recognized in the nucleus of nerve cells and oligodendroglia cells.
In other words, the case was histopatholgically regarded as a case of acute diffuse meningoencephalitis with inclusion bodies.
