Abstract
Human chromogranin A (CgA) in saliva has been used as a stress marker in recent years, however,there have been some negative reports about it. In a pilot study of 88 boys and 90 girls we examined whether CgA was related to Frankl's Behavior Rating Scale and whether it can be applied in today's dental practice through the fisher sealant. The following conclusions were obtained.1.The value of CgA, [after 10 minutes of treatment] was 17.560±12.544 pmol/mg protein, [immediately before treatment] was 16.075±13.019 pmol/mg protein and [10 minutes after treatment] was 11.764±10.239 pmol/mg protein. Moreover, a significant difference was observed between [immediately before treatment] and [10 minutes after treatment], and between [after 10 minutes of treatment] and [10 minutes after treatment], and no significant difference between the sexes was observed.2.A significant negative correlation was observed between the age and the value of CgA at [after 10 minutes of treatment] and [immediately before treatment].3.No relation was observed between the value of CgA and the measurement time.4.Frankl's Behavior Rating Scale was observed in order of Class 3, Class 4, and Class 2.5.A significant correlation was not observed between Frankl's Behavior Rating Scale and the value of CgA in all ages.Quantiative changes in CgA tended to reflect psychological stress, however, it is highly variable and it is almost impossible to arrange conditions for measuring it. It appears that a single clinical application of CgA in saliva is time dependent.
