Article ID: 10779
Background and Purpose: Ovarian clear cell carcinoma (OCCC) has been reported to have increased risks of thromboembolic events from early stages. However, clinical characteristics of cerebral infarction and thromboembolism, is known as Trousseau syndrome, associated with OCCC have not been clearly elucidated. Therefore, we investigated clinical characteristics of patients with Trousseau syndrome and constituent cerebral infarction associated with OCCC. Methods: We compared cerebral infarction encountered in OCCC with those associated with other malignancies among patients who were admitted to our hospital between January 2012 and December 2017. Plasma D-dimer and CA-125 values, characteristics of cerebral infarction, timing of the onset of cerebral infarction, outcomes etc. were investigated. We identified 21 patients with OCCC in the literature and added them to our analyses. Results: There were four patients with OCCC and other four patients with cancers. Plasma CA-125 levels were high in all patients with OCCC, whereas plasma D-dimer levels were high in all eight patients. All four patients with OCCC had cerebral infarction prior to cancer diagnosis, and three patients survived for more than two years. All four patients with other cancers had cerebral infarction during cancer treatment, and died within four months after the onset of cerebral infarction. Conclusion: The patients with Trousseau syndrome associated with OCCC had acute cerebral infarction prior to the cancer diagnosis and the prognosis tended to be good. Clinical feature of Trousseau syndrome associated with OCCC appears to be different from the same syndrome associated with other cancers.
