1958 Volume 46 Issue 11 Pages 1437-1449
The leucocytosis promoting effects have been studied by the administration of cysteine and typhoid vaccine (T.V.), a kind of typical centrally leucocyte increasing substance, to the rabbits with the hematopoietic organs injured by Nitromin. Cysteine and T.V. were administered at times when the above injury proved strongest and slight. The results obtained were as follows:
1. As in the case of the strongest injury, the promoting effects of cysteine and T.V. were weak and delayed.
2. As in the case of the strongest injury, the first peak of the two-peaked phase never appeared and the second one was remarkably delayed and low. The initial negative phenomenon by the injection of T.V. appeared irrespective of the degree of the injury, but in the case of the strongest injury, the duration of the phenomenon were prolonged.
3. As in the case of the slight injury, both cysteine and T.V. produced a regular marked promoting effect on the leucocyte count.
4. Since the injury of the leucocyte-storing organs was found slight even in the case of the strongest injury (of the hematopoietic organs), the leucocyte mobilizing action of cysteine was not by releasing the stored leucocytes.
5. When the hematopoietic organs were injured, the leucocyte increasing effect of T.V. was more noted than that of cysteine. This difference is induced by the temporary alteration of the periphere vessels and means that T.V. injection produces a marked retaining action on peripheral leucocytes.
