THE ROLE OE PANCREOZYMIN AND SECRETIN ON PANCREATIC ENZYME SYNTHESIS AND SECRETION IN THE RAT

Abstract

The role of pancreozymin (PZ) and secretin (SC) on synthesis and secretion of the pancreatic enzymes was studied in vivo using ⁷⁵Selen-laveled methionine as a precursor in normal rat. Pancreatic juice was collected by canulation for determination of amylase activity, protein concentration, protein-bound ⁷⁵Selen-radioactivity and volume of pancreatic juice before and after PZ or SC stimulation. Following results were obtained.
(1) ⁷⁵Selen-radioactivity in the pancreatic juice corresponds to the pancreatic exocrine function, (2) ⁷⁵Se-selenomethionine was incorporated into pancreatic enzymes and (3) it was suggested that PZ and SC stimulated enzyme synthesis as well as its release and that SC showed dominant effect in synthesis of enzymes.