HBs抗原持続陽性者における各種HBVマーカーの測定 特にHBs抗原の母児間垂直感染について

岩間 章介; 中山 隆雅; 土屋 聖二; 檜山 義明; 後藤 信明; 横須賀 収; 河野 邦彦; 大槻 俊夫; 大西 久仁彦; 中嶋 征男; 小俣 政男; 武者 広隆; 奥田 邦雄; 稲葉 憲之; 大川 玲子; 高見沢 裕吉

doi:10.11405/nisshoshi1964.78.2144

DETECTION OF VARIOUS HBV MARKERS IN ASYMPTOMATIC HBsAg CARRIERS

Importance of Sensitivity of the Methods used in the Setting when Mother-Infant Transmission is Possible

Shousuke IWAMA, Takatsune NAKAYAMA, Seiji TSUCHIYA, Yoshiaki HIYAMA, Nobuaki GOTOH, Osamu YOKOSUKA, Kunihiko KOHNO, Toshio OHTSUKI, Yukio NAKAJIMA, Kunihiko OHNISHI, Masao OMATA, Hirotaka MUSHA, Kunio OKUDA, Noriyuki INABA, Reiko OHKAWA, Hiroyoshi TAKAMIZAWA

Author information

Shousuke IWAMA
The First Department of Internal Medicine, Chiba University School of Medicine
Takatsune NAKAYAMA
The First Department of Internal Medicine, Chiba University School of Medicine
Seiji TSUCHIYA
The First Department of Internal Medicine, Chiba University School of Medicine
Yoshiaki HIYAMA
The First Department of Internal Medicine, Chiba University School of Medicine
Nobuaki GOTOH
The First Department of Internal Medicine, Chiba University School of Medicine
Osamu YOKOSUKA
The First Department of Internal Medicine, Chiba University School of Medicine
Kunihiko KOHNO
The First Department of Internal Medicine, Chiba University School of Medicine
Toshio OHTSUKI
The First Department of Internal Medicine, Chiba University School of Medicine
Yukio NAKAJIMA
The First Department of Internal Medicine, Chiba University School of Medicine
Kunihiko OHNISHI
The First Department of Internal Medicine, Chiba University School of Medicine
Masao OMATA
The First Department of Internal Medicine, Chiba University School of Medicine
Hirotaka MUSHA
The First Department of Internal Medicine, Chiba University School of Medicine
Kunio OKUDA
The First Department of Internal Medicine, Chiba University School of Medicine
Noriyuki INABA
Department of Obstetrics and Gynecology, Chiba University School of Medicine
Reiko OHKAWA
Department of Obstetrics and Gynecology, Chiba University School of Medicine
Hiroyoshi TAKAMIZAWA
Department of Obstetrics and Gynecology, Chiba University School of Medicine

JOURNAL FREE ACCESS

1981 Volume 78 Issue 11 Pages 2144-2150

DOI https://doi.org/10.11405/nisshoshi1964.78.2144

Details

Abstract

Various HBV markers were measured in 106 asymptomatic HBsAg carriers and in 76 infants born from asymptomatic HBsAg carrier mothers. The radioimmunoassay method was more sensitive than the Micro-Ouchterlony method for the detection of HBeAg and anti-HBe in asymptomatic HBsAg carriers. The former was more useful than the latter for predicting the vertical transmission of HB virus from asymptomatic HBsAg carrier mothers to their infants and subsequent development of carrier state. Anti-HBc in cord blood in the infants born from asymptomatic HBsAg carrier mothers was derived from the antibody transmitted trans-placentally from the mother, and disappeared in 1 to 1.5 years when no HBV infection occurred.

Corresponding author