Japanese Journal of Biometrics
Online ISSN : 2185-6494
Print ISSN : 0918-4430
ISSN-L : 0918-4430
Volume 42, Issue 2
Displaying 1-2 of 2 articles from this issue
Original Article
Preliminary Report
  • Hideaki Uehara, Kazuko Satoh, Nagisa Komokata, Kazuo Ogawa
    2022 Volume 42 Issue 2 Pages 83-106
    Published: 2022
    Released on J-STAGE: June 08, 2022

    In ex vivo dose-response experiments with multiple animals, it is common to observe variation in the shape of the dose-response curves between animals. This heterogeneity may be explained to some extent by the differences in responsiveness between specimens, which is typically evaluated in two ways:spontaneous reactions with and without the standard stimulant at baseline. If available, these covariates may be used to predict a specimen’s maximal and minimal responses. Meanwhile, the between-substance similarities in dose-response curves are crucial in relative potency estimation. In a parallel-line assay, for example, we need to demonstrate the parallelism between dose-response slopes. When using multiple animals, it is also crucial to confirm the similarity within each animal(Uehara et al. 2016a).This paper discusses the appropriate use of the above-noted covariates to assess intrasubject parallelism(Uehara 2018).The influence of the covariates on the dose-response curve is investigated in order to improve the efficiency of the intrasubject parallelism assessment and enhance the precision of the parameter estimates. An example is introduced to demonstrate the proposed method, and simulation study results are reported.

    Download PDF (1556K)