Annual Meeting of the Japanese Society of Toxicology

Annual Meeting of the Japanese Society of Toxicology

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The 42nd Annual Meeting of the Japanese Society of Toxicology

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Poster Session 2

Induction of necroptotic cell death by photodynamic therapy with laserphyrin in glioblastoma cells

Yuichi MIKI, Aya SATOH, Chihiro HIRONAKA, Jiro AKIMOTO, Yasuyuki FUJIW ...

Session ID: P-58
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-58

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Treatment of photodynamic therapy using laserphyrin induces cell death in malignant meningioma

Jun MAEDA, Yuichi MIKI, Megumi ICHIKAWA, Jiro AKIMOTO, Yasuyuki FUJIWA ...

Session ID: P-59
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-59

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Restrain of erythropoietin production in HepG2 cell enhances the anti-tumor effect of cisplatin

Kazuhiko NISHIMURA, Yuuki YONEZAWA, Hiroshi NAKAGAWA, Saburo MATSUO

Session ID: P-60
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-60

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Effect of tributyltin on mitochondrial quality control

Shigeru YAMADA, Yaichiro KOTAKE, Mizuho NAKANO, Yuko SEKINO, Yasunari ...

Session ID: P-61
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-61

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Mechanism of nuclear respiratory factor-1 inhibition involved in organotin induced neurotoxicity

Keishi ISHIDA, Yaichiro KOTAKE, Kaori AOKI, Tomoko TAKISHITA, Tomoki K ...

Session ID: P-62
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-62

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Role of putrescine in methylmercury-induced apoptosis

Masayuki SATO, Akira NAGANUMA, Gi-Wook HWANG

Session ID: P-63
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-63

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Methylmercury induces brain-specific expression of secretoglobin 3A1

Tsutomu TAKAHASHI, Min-Seok KIM, Takahiro SAITO, Qian ZHAO, Miyuki IWA ...

Session ID: P-64
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-64

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Effects of cadmium on the ubiquitinated protein in human proximal tubular cells

Jin-Yong LEE, Akihiro TAMAGAWA, Chisato WATANABE, Maki TOKUMOTO, Masah ...

Session ID: P-65
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-65

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An organorhodium compound that suppresses the expression of perlecan in vascular endothelial and smooth muscle cells

Hiroka MATSUZAKI, Takato HARA, Eiko YOSHIDA, Yasuyuki FUJIWARA, Chika ...

Session ID: P-66
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-66

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Mechanisms underlying VEGF induction by methylmercury in cultured human brain microvascular pericytes

Kenta SAKURAI, Eiko YOSHIDA, Chika YAMAMOTO, Toshiyuki KAJI

Session ID: P-67
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-67

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Induction of aldose reductase expression in cultured human brain microvascular pericytes after exposure to methylmercury

Tomoko SASAOKA, Eiko YOSHIDA, Chika YAMAMOTO, Toshiyuki KAJI

Session ID: P-68
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-68

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Methylmercury toxicity in the fibrinolytic system of cultured human brain microvascular endothelial cells

Miho TANAKA, Masaru KURITA, Eiko YOSHIDA, Chika YAMAMOTO, Toshiyuki KA ...

Session ID: P-69
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-69

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The cytotoxicity of orgnoantimony compounds in cultured vascular endothelial cells

Tomoya FUJIE, Masaki MURAKAMI, EIko YOSHIDA, Chika YAMAMOTO, Yasuyuki ...

Session ID: P-70
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-70

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Characteristics of cell clones resistant to organobismuth or organoantimony compounds

Yuta KONNO, Shizuka NAKASAKO, Eiko YOSHIDA, Yasuyuki FUJIWARA, Chika Y ...

Session ID: P-71
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-71

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The substituent effects on the cytotoxicity of diphenylditelluride in cultured vascular endothelial cells

Takahiro OKAZAKI, Shizuka NAKASAKO, Eiko YOSHIDA, Yasuyuki FUJIWARA, C ...

Session ID: P-72
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-72

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DNA methylation change of LINE1 in genomic DNA derived from blood of people living in arsenic- endemic and non-endemic areas in Bangladesh

Takehiro SUZUKI, Khaled HOSSAIN, Seiichiro HIMENO, Keiko NOHARA

Session ID: P-73
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-73

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Study on metabolite and hepatotoxicity after exposure to 1,2-dichloropropane in vitro and vivo

Yukie YANAGIBA, Megumi SUDA, Rui-Sheng WANG

Session ID: P-74
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-74

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Mode of action of ethyl-tertiary-butyl ether tumorigenicity in the rat liver: Evidence for oxidative stress induction via activation of CAR, PXR and PPARs

Anna KAKEHASHI, Akihiro HAGIWARA, Norio IMAI, Min WEI, Shoji FUKUSHIMA ...

Session ID: P-75
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-75

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Evaluation of heavy metal adsorption effect by alginate

Takuo OGIHARA, Yoko IDOTA, Takako KATO, Kentaro YANO, Hiroshi ARAKAWA, ...

Session ID: P-76
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-76

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Perfluorooctanoic acid accelerates fatty acid oxidation in rat liver slices

Kohei KAWABATA, Yoichi KAWASHIMA, Naomi KUDO

Session ID: P-77
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-77

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Is one year repeated toxicity study in dogs unnecessary for the risk assessments of the agrochemical compounds?

Daisuke MUKAI, Ryota TANAKA, Masato NAYA, Makoto HAYASHI

Session ID: P-78
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-78

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Initial serum ammonia as a predictor of complications in patients with acute glufosinate poisoning

Dongkeon LEE, Hyun YOUK, Hyun KIM, Yongsung CHA

Session ID: P-79
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-79

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Purpose: Glufosinate poisoning can cause complications that may be difficult to treat due to their delayed manifestation. Studies assessing possible predictors of complications are lacking. Although serum ammonia level is a probable predictor of severe neurotoxicity, it has only been assessed via case reports. Therefore, we investigated factors that predict complications in acute glufosinate-poisoned patients.
Materials and Methods: We conducted a retrospective review of 45 consecutive glufosinate poisoning cases that were diagnosed and treated in the emergency department of Wonju Severance Christian Hospital between May 2007 and July 2014. The patients were divided into a severe group, defined as patients with Glasgow Coma Scale (GCS)<8, seizure, amnesia, respiratory failure, shock, pneumonia, acute kidney injury, and death, while the non-severe group included patients with none of these complications.
Results: The severe group included 29 patients (64.4%). The complications were GCS<8 (27 patients, 60.0%), seizure (23 patients, 51.1%), respiratory failure (14 patients, 31.1%), shock (2 patients, 4.4%), pneumonia (16 patients, 35.6%), acute kidney injury (10 patients, 22.2%), and death (4 patients, 8.9%), respectively. Initial serum ammonia was a predictor of complications [odds ratio 1.039, 95% confidence interval (1.001-1.078), p=0.046]. The optimal point for initial serum ammonia was 86 ug/dL [sensitivity: 72%, specificity: 64%, and area under the curve 0.742].
Conclusion: Complications developed in 64.4% of patients with acute glufosinate poisoning. The most common complication was GCS<8. Initial serum ammonia level>86 ug/dL could be a predictor of complications that can be readily assessed in the ED for acute glufosinate-poisoned patients.

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Recognition of the oxidized LDL by macrophage surface receptor protein nucleolin

Yukari OHMINATO, Yuichi MIKI, Yoshihiro TACHIBANA, Masatoshi BEPPU, Ya ...

Session ID: P-80
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-80

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Macrophage surface receptor nucleolin is a receptor for maleylated-bovine serum albumin (BSA)

Haruna KURUSU, Keisuke KOYAMA, Yuichi MIKI, Masatoshi BEPPU, Yasuyuki ...

Session ID: P-81
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-81

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Development of cancer chemotherapeutics that cause minimal side effects-"Does cancer cell cling to life?"

Rina YOKOKAWA, Ryo SAKURAI, Hideaki HIGURASHI, Tomofumi FUJINO, Makio ...

Session ID: P-82
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-82

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Reactive sulfur species-mediated activation of the Keap1-Nrf2 pathway by 1,2-naphthoquinone through sulfenic acids formation under oxidative stress

Yasuhiro SHINKAI, Takashi MIURA, Hidenao KAKEHASHI, Takaaki AKAIKE, Yo ...

Session ID: P-83
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-83

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Na₂S₄, a reactive sulfur species, reduces 1,4-NQ induced cytotoxicity through sulfur adduct formation

Takamitsu UNOKI, Yasuhiro SHINKAI, Yoshito KUMAGAI

Session ID: P-84
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-84

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Regulation mechanism of the constitutive androstane receptor (CAR) by newly identified CAR binding proteins

Yuichiro KANNO, Yuki KURE, Hikari SHIRAISHI, Yoshio INOUYE

Session ID: P-85
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-85

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Effect of selenomethionine on active cutaneous anaphylaxis reaction

Tomohiro ARAKAWA, Takuma HIROOKA, Takahiro SUGIYAMA, Hirofumi OGINO, T ...

Session ID: P-86
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-86

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Metallothionein: Possibility as toxicity marker of metal-oxide nanoparticle

Masanori HORIE, Yosuke TABEI, Sakiko SUGINO, Yoshihiro NAKAJIMA, Yasuk ...

Session ID: P-87
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-87

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Effect of nanomaterial on permeability of blood-placenta barrier

Yuki SHIMIZU, Yasuo YOSHIOKA, Yuki MORISHITA, Yuya TAKIMURA, Yuki NAMB ...

Session ID: P-88
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-88

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Digestion of spleen assisted by ultrasonic irradiation with proteinase K and determination of single-walled carbon nanotubes content based on visible light absorbance

Junko MARU, Shigehisa ENDOH, Katsuhide FUJITA

Session ID: P-89
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-89

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Fundamental data of intratracheal instillation study in pregnant mice

Sho TANAKA, Yusuke SAEKI, Yukari ODAGIRI, Kana NANAMI, Keiichi ITOH, H ...

Session ID: P-90
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-90

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Coparison of fetal toxicity of various multi-wall carbon nanotubes in mice

Tomoko FUJITANI, Akiko INOMATA, Akio OGATA, Hiroshi ANDO, Yoshikazu KU ...

Session ID: P-91
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-91

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The mechanism analysis of silica nanoparticles-induced acute toxicity focused on platelet

Takayuki HANDA, Yasuo YOSHIOKA, Toshiro HIRAI, Nobuo NISHIJIMA, Natsum ...

Session ID: P-92
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-92

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The identification of a cell type that concerned about the pathogenesis of metal allergy in animal model mediated by metal nanoparticles

Natsumi IZUMI, Yasuo YOSHIOKA, Toshiro HIRAI, Nobuo NISHIJIMA, Takayuk ...

Session ID: P-93
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-93

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Effects of nanoparticles on DNA methylation on alveolar epithelial cells

Ayaka MAKI, Kazuma HIGASHISAKA, Yuki NISHIKAWA, Yasuo YOSHIOKA, Yasuo ...

Session ID: P-94
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-94

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Effects of zinc oxide nanomaterials on the cellular responses in vitro

Atsuko MIYAJIMA, Tsuyoshi KAWAKAMI, Kaoru KOMORIYA, Reiko KATO, Shingo ...

Session ID: P-95
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-95

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Effect of toxicity and drug interactions by nano-platinum particles

Katsuhiro ISODA, Tomomi DAIBO, Kaori YUSHINA, Yuitiro TAIRA, Ikuko TAI ...

Session ID: P-96
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-96

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The effects on the mice central nervous system by titanium dioxide nanoparticles

Megumi SUDA, Rieko HOJO, Nobuhiko MIURA, Yukie YANAGIBA, Tetsuya SUZUK ...

Session ID: P-97
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-97

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Biological responses to multi-walled carbon nanotubes in brain related cell lines

Hisao HANIU, Naoto SAITO, Kayo MARUYAMA, Yoshikazu MATSUDA, Kaoru AOKI ...

Session ID: P-98
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-98

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Evaluation of the adjuvant effects of epicutaneously exposed silver nanoparticles in mouse model

Young-Man CHO, Yasuko MIZUTA, Takeshi TOYODA, Junichi AKAGI, Tadashi H ...

Session ID: P-99
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-99

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Genotoxic effect of intratracheally instilled titanium dioxide nanoparticles in the lungs of mice

Rui-Sheng WANG, Rieko HOJO, Akinori YASUDA, Megumi SUDA, Yukie YANAGIB ...

Session ID: P-100
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-100

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Biological responses of peapod-CNT in vitro

Kayo MARUYAMA, Hisao HANIU, Shinsuke KOBAYASHI, Shuji TSURUOKA, Yoshik ...

Session ID: P-101
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-101

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Revealed features of MWCNT-7 (multi-walled carbon nano tube)observed in rats carcinogenicity study

Tatsuya KASAI, Yumi UMEDA, Makoto OHNISI, Masumi ASAKURA, Shoji FUKUSH ...

Session ID: P-102
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-102

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Analysis of pulmonary toxicity and AUC obtained from lung deposition amount for whole body exposure in rats using the low level measurement method (marker method) of multi-walled carbon nanotubes

Makoto OHNISHI, Tatsuya KASAI, Yumi UMEDA, Shoji FUKUSHIMA

Session ID: P-103
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-103

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Biological effects of multi wall carbon nanotube by intratracheal administration

Masaaki SUZUKI, Hirokazu KANO, Hideki SENOH, Hitomi KONDO, Tadao TOYA, ...

Session ID: P-104
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-104

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Evaluation of teratogenicity of multi-wall carbon nanotubes in pregnant mice after single and repeated intratracheal instillation

Norihiro KOBAYASHI, Sho TANAKA, HIroshi TAKEHARA, Masato NAYA, Reiji K ...

Session ID: P-105
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-105

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The characterization and determination of the nano-particle in the environmental and biological sample using by single particle(SP)-ICP-MS

Kyoko KOBAYASHI, Osamu SHIKINO, Aaron HINEMAN, Chady STEPHAN

Session ID: P-106
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-106

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Cell viability of nanomaterial-mixed conditions - Zinc oxide nanoparticles and dental monomer -

Tsubasa SHIRAI, Koichi IMAI

Session ID: P-107
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_P-107

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