Abstract
The flow rate ν and column length L are simultaneously optimized in liquid chromatography with the aid of the information measure, FUMI Φ, and its related functions: the information flow υ and information loss δΦ. Two types of the optimal conditions are selected for the liquid-chromatographic analysis of an antipyretics mixture. For the most precise analysis (Φ-optimal), the shortest possible column and a low flow rate ν are recommended. A slightly longer column than the Φ-optimal L and a higher υ are recommended for the most efficient (rapid) analysis (υ-optimal). Both the Φ- and υ-optimals avoid strong peak overlap. The above-mentioned operational difference of the optimals is obtained by the computer simulation of chromatograms of the antipyretics.
