Abstract
ATAT-2266 was evaluated bacteriologically in comparison with Norfloxacin (NFLX), Pipemidic acid (PPA) and Nalidixic acid (NA) and the following results were obtained.
1. ATAT-2266 had a broad spectrum of antibacterial activity against gram- positive and gram- negative anaerobic bacteria (except for C. difficile and C. ramosum) and the antibacterial activity of ATAT-2266 was stronger those of PPA and NA. The activity of ATAT-2266 against anaerobic bacteria was same activity those of NFLX.
2. Bactericidal effect of ATAT-2266 against Bacteroides was same to that of NFLX and was strong.
3. ATAT-2266 exhibited an excellent chemotherapeutic effect against polymicrobial subcutaneously infections in mice due to β- lactamase producing E. coli and B. fragilis.
