1984 Volume 32 Issue Supplement3 Pages 18-33
In vitro and in vivo antibacterial activities of ATAT-2266, a new pyridonecarboxylic acid antibacterial agent, were compared with those of the same class of antibacterial agents, norfloxacin and pipemidic acid, and the following results were obtained.
ATAT-2266 was active against gram-positive and gram- negative organisms, especially E. coli, Shigella, Salmonella, Klebsiella (K. pneumoniae, K. oxytoca), Proteus sp.(P. mirabilis, P. vulgaris, P. morganii), E. cloacae and S. epidermidis. It was more active than pipemidic acid and as active as or slightly less active than norfloxacin.
ATAT-2266 was as active as norfloxacin against P. aeruginosa and S. marcescens, and more active than norfloxacin or pipemidic acid against fermentative organisms, such as P. maltophilia, P. cepacia, A. faecalis and F. meningosepticum.
It was found that ATAT-2266 had a more potent bactericidal activity against E. coli than did norfloxacin and pipemidic acid.
ATAT-2266 was superior to norfloxacin and pipemidic acid in protecting infections with K. pneumoniae, P. vulgaris, P. aeruginosa and A. calcoaceticus in experimental infections in mice.
