Thrombomodulin, An Endothelial Anticoagulant : Its Structure, Function and Expression : ROLES OF VASCULAR ENDOTHELIUM IN REGULATION OF CARDIOVASCULAR SYSTEM

IKURO MARUYAMA

doi:10.1253/jcj.56.187

JAPANESE CIRCULATION JOURNAL

Online ISSN : 1347-4839
Print ISSN : 0047-1828
ISSN-L : 0047-1828

Thrombomodulin, An Endothelial Anticoagulant : Its Structure, Function and Expression : ROLES OF VASCULAR ENDOTHELIUM IN REGULATION OF CARDIOVASCULAR SYSTEM

IKURO MARUYAMA

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Keywords: Endothelial cells, Thrombomodulin, Protein C, Cytokine, Thrombosis

JOURNAL FREE ACCESS

1992 Volume 56 Issue 2 Pages 187-191

DOI https://doi.org/10.1253/jcj.56.187

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Abstract

Thrombomodulin is an endothelium-associated glycoprotein that coverts thrombin from a procoagulant protease to an anticoagulant. Thrombin, a key enzyme in thrombus formation, binds to thrombomodulin on the endothelium. However after thrombin binds to thrombomodulin, it fails to act on the coagulation factors and platelets, and its ability to activate protein C is enhanced more than 1, 000-fold. This article reviews the recent progress in the study of thrombomodulin.

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