Small Bowel Perforation Caused by Epstein-Barr Virus-Associated B Cell Lymphoma in a Patient with Angioimmunoblastic T-Cell Lymphoma

Tsutomu Takahashi; Riruke Maruyama; Satoko Mishima; Masaya Inoue; Koshi Kawakami; Chie Onishi; Takaaki Miyake; Junko Tanaka; Toru Nabika; Hiroto Ishikura

doi:10.3960/jslrt.50.59

Case Study

Small Bowel Perforation Caused by Epstein-Barr Virus-Associated B Cell Lymphoma in a Patient with Angioimmunoblastic T-Cell Lymphoma

Tsutomu Takahashi, Riruke Maruyama, Satoko Mishima, Masaya Inoue, Koshi Kawakami, Chie Onishi, Takaaki Miyake, Junko Tanaka, Toru Nabika, Hiroto Ishikura

Author information

Tsutomu Takahashi
Department of Hematology, Shimane University Faculty of Medicine
Riruke Maruyama
Department of Organ Pathology, Shimane University Faculty of Medicine
Satoko Mishima
Department of Functional Pathology, Shimane University Faculty of Medicine
Masaya Inoue
Division of Clinical Study of Oncology, Shimane University Hospital
Koshi Kawakami
Department of Hematology, Shimane University Faculty of Medicine
Chie Onishi
Department of Hematology, Shimane University Faculty of Medicine
Takaaki Miyake
Department of Hematology, Shimane University Faculty of Medicine
Junko Tanaka
Department of Hematology, Shimane University Faculty of Medicine
Toru Nabika
Department of Functional Pathology, Shimane University Faculty of Medicine
Hiroto Ishikura
Division of Clinical Study of Oncology, Shimane University Hospital

Keywords: angioimmunoblastic T-cell lymphoma, small bowel perforation, Epstein-Barr virus, secondary B cell lymphoma

JOURNAL FREE ACCESS

2010 Volume 50 Issue 1 Pages 59-63

DOI https://doi.org/10.3960/jslrt.50.59

Details

Abstract

On rare occasions, secondary Epstein-Barr virus (EBV)-associated B cell lymphoma can develop in a patient with angioimmunoblastic T-cell lymphoma (AITL). We report a case of a 66-year-old Japanese woman who developed diffuse large B-cell lymphoma (DLBCL) in her small intestine after chemotherapy for AITL. She was found to have panperitonitis due to perforation of the small intestine. Partial ileectomy specimen showed DLBCL cells infiltrating into the intestinal wall. In situ hybridization for EBV-encoded RNA revealed positivity in the lymphoma cells. The lymph nodes diagnosed as AITL were negative for EBV infection and there was no coexistence of B cell neoplasms in them. We thought small bowel perforation in this case was caused by EBV-associated B cell lymphoma secondary to AITL. Our case showed a remarkable deficiency of cellular immunity after chemotherapy, which we postulate was related to the cause of occurrence of B-cell lymphoma. [J Clin Exp Hematopathol 50(1) : 59-63, 2010]

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