Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics

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21st JSSX Annual Meeting

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President's Lecture

Message from the JSSX President

Yuichi Sugiyama

Session ID: President's Lecture
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.104.1

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Distinguished Lectures

STRUCTURE AND FUNCTION OF MAPEG: LESSONS FROM THE CRYSTAL STRUCTURE OF MICROSOMAL GLUTATHIONE TRANSFERASE 1

Ralf Morgenstern

Session ID: D1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.146.1

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Genetic Susceptibility to Severe Adverse Drug Reactions: Perspective for Future Medicine

Yuang-Tsong Chen

Session ID: D2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.129.1

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Idiosyncratic Drug Hepatotoxicity: Insights from Acetaminophen Toxicity in the Mouse

Neil Kaplowitz

Session ID: D3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.109.1

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EPIGENETICS, A NEW PARADIGM OF LIFE SCIENCES

Kunio Shiota

Session ID: D4
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.166.1

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Symposium 1
The relevance of transporters to the efficacy and toxicity of drugs
(Asia-Pacific ISSX-JSSX Joint Symposium)

Symposium 2
Chemically reactive metabolites
(JSSX Session)

PREDICTION OF DRUG-DRUG INTERACTIONS BASED ON TIME-DEPENDENT INHIBITION FOR CYPS ON DRUG DISCOVERY STAGES

Atsuko Higashida, Motohiro Kato, Nobuo Sekiguchi, Tetsuya Mitsui, Masa ...

Session ID: 29S2A-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.126.1

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MECHANISM-BASED INACTIVATION STUDIES FOR DRUG DESIGN

Yoshimasa Kobayashi, Hideo Yukinaga, Osamu Okazaki, Kenichi Sudo, Chit ...

Session ID: 29S2A-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.127.1

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DETECTION OF REACTIVE METABOLITES IN DRUG DISCOVERY USING TRAPPING AGENTS AND LC/MS TECHNIQUE

Kazuyoshi Nozaki, Kazuyo Nakagawa, Kaori Tanimoto, Masayuki Kubota, Su ...

Session ID: 29S2A-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.128.1

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Symposium 3
Chemically reactive metabolites
(ISSX-JSSX Joint Symposium)

Biomarker Discovery by Metabolome Analysis - Signature Molecules of Exposure to Chemically Reactive Metabolites

Tomoyoshi Soga

Session ID: 29S3A-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.132.1

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MECHANISMS OF CYTOCHROME P450 ENZYMES THAT CONTROL DEHYDROGENATION VS. OXYGENATION OF XENOBIOTICS

Garold S. Yost

Session ID: 29S3A-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.133.1

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METABOLIC ACTIVATION AND DRUG INDUCED HEPATOTOXICITY - THE TROGLITAZONE CASE -

Tsuyoshi Yokoi

Session ID: 29S3A-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.134.1

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THE CHEMISTRY OF REACTIVE METABOLITES AS IT RELATES TO STRUCTURE/TOXICITY RELATIONSHIPS

Sidney D. Nelson

Session ID: 29S3A-4
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.135.1

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Symposium 4
Functional relation between drug metabolizing enzymes and transporters

STURUCTURE, FUNCTION AND REGURATORY MECHANISM OF HUMAN CARBOXYLESTERASE ISOZYMES

Masakiyo Hosokawa, Naoko Yamamoto, Yumiko Yaginuma, Yuko Nagahara, Mik ...

Session ID: 29S4B-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.138.1

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CELLULAR BEHAVIOR OF PRODRUG: TRANSPORT AND HYDROLYSIS

Teruko Imai, Kayoko Oura, Mayumi Shii, Megumi Taketani, Mitsuru Hashim ...

Session ID: 29S4B-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.139.1

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OXIDATIVE STRESS RESPONSE OF MRP TRANSPORTER REGULATION

Kousei Ito, Shuichi Sekine, Hiroshi Suzuki, Toshiharu Horie

Session ID: 29S4B-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.140.1

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INTERPLAY BETWEEN BREAST CANCER RESISTANCE PROTEIN AND SULFOTRANSFERASES

Junichi Enokizono, Hiroyuki Kusuhara, Yasuhisa Adachi, Alfred H Schink ...

Session ID: 29S4B-4
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.141.1

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ENHANCED EXPRESSION OF HEPATIC UDP-GLUCURONOSYLTRANSFERASES AND DRUG TRANSPORTERS IN RATS FED A HIGH-FAT AND HIGH-SUCROSE DIET

Junko Sugatani, Makoto Osabe, Tomoaki Fukuyama, Shin-Ichi Ikushiro, Ta ...

Session ID: 29S4B-5
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.142.1

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FUNCTIONAL INTERACTION OF CYP3A4 AND UGT2B7: POSSIBLE INVOLVEMENT OF THE REGIONS BETWEEN Arg268 AND Asp404 OF CYP3A4 IN THE INTERACTION

Yuji Ishii, Shuso Takeda, Peter I. Mackenzie, Kiyoshi Nagata, Yasushi ...

Session ID: 29S4B-6
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.143.1

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Symposium 5
Relationship between phase II drug-metabolizing enzymes and drug action

POLYMORPHISM OF UDP-GLUCURONOSYL TRANSFERASE 1A7 (UGT1A7) AS A POSSIBLE RISK FACTOR FOR LUNG CANCER AND LINKAGE DISEQUILIBRIUM AMONG UGT1A1, 1A6 AND 1A7

Yoshinao Kobayashi, Jun Araki, Naohito Urawa, Yukihiko Adachi

Session ID: 29S5B-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.148.1

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ACQUIRED TAMOXIFEN REGISTANCE IN MCF-7 CELLS BY OVEREXPRESSION OF UDPGLUCURONOSYLTRANSFERASE

Kenichiro Ogura, Kenichi Yanagibashi, Tomokazu Ohnuma, Takahito Nishiy ...

Session ID: 29S5B-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.149.1

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HYPOCHOLESTEROLEMIC ACTION AND HEPATOBILIARY TRANSPORT OF METHYL-1-(3,4-DIMETHOXYPHENYL)-3-(3-ETHYLVALERYL)-4-HYDROXY-6,7,8-TRIMETHOXY-2-NAPHTHOATE (S-8921) GLUCURONIDE

Shingo Sakamoto, Kazutoshi Horie, Takahiko Baba, Hiroyuki Kusuhara, Yu ...

Session ID: 29S5B-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.150.1

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PROTECTIVE ROLE OF HYDROXYSTEROID SULFOTRANSFERASE IN SECONDARY BILE ACID-INDUCED LIVER TOXICITY

Masaaki Miyata, Wataru Hori, Hirotaka Watase, Miki Shimada, Yasushi Ya ...

Session ID: 29S5B-4
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.151.1

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FUNCTIONS OF GLUTATHIONE TRANSFERASES IN RAT HEPATOCARCINOGENESIS

Shigeki Tsuchida

Session ID: 29S5B-5
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.152.1

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Symposium 6
New strategies in drug transporter research: from QSAR analysis to drug molecular imaging

OVERVIEW: GENETIC POLYMORPHISMS OF ABCG2 AND QSAR ANALYSIS

Toshihisa Ishikawa, Ai Tamura, Kanako Wakabayashi, Hikaru Saitou, Yuko ...

Session ID: 30S6A-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.154.1

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QSAR ANALYSIS OF ABCB11 (BSEP) AND PREDICTION OF DRUG-INDUCED INTRAHEPATIC CHOLESTASIS

Hiroyuki Hirano

Session ID: 30S6A-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.155.1

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GENETIC POLYMORPHISMS OF ABCB1 (P-GLYCOPROTEIN/MDR1) AND QSAR ANALYSIS

Aki Sakurai

Session ID: 30S6A-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.156.1

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3D-QSAR ANALYSES USING LIGAND-BASED DRUG DESIGN METHODS: HUMAN AND RAT OCT1

Shuichi Hirono

Session ID: 30S6A-4
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.157.1

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NEW ASPECTS OF IN-VIVO MOLECULAR IMAGING BY PET

Masaaki Suzuki

Session ID: 30S6A-5
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.158.1

CONFERENCE PROCEEDINGS FREE ACCESS

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Symposium 7
Recent progress in DMPK sciences

PROTEOMIC PROFILING OF FORMALIN-FIXED PATHOLOGICAL TISSUES BY MASS SPECTROMETRY (I)

Akira Honda, Mikio Doy, Tomoyo Nakano, Yasuhiko Bando, Yasushi Matsuza ...

Session ID: 30S7B-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.160.1

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IMPROVEMENT OF ORAL DRUG ABSORPTION THROUGH THE INHIBITION OF BREAST CANCER RESISTANT PROTEIN BY PHARMACEUTICAL EXCIPIENTS

Tetsuo Yamagata, Hiroyuki Kusuhara, Mariko Morishita, Kozo Takayama, Y ...

Session ID: 30S7B-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.161.1

CONFERENCE PROCEEDINGS FREE ACCESS

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HUMAN CYP1B1 IS REGULATED BY MICRORNA, MIR-27B

Shingo Takagi, Yuki Tsuchiya, Miki Nakajima, Miki Katoh, Takao Taniya, ...

Session ID: 30S7B-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.162.1

CONFERENCE PROCEEDINGS FREE ACCESS

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Aldehyde oxidase and CYP2C9-dependent drug metabolism in vivo and in vitro in chimeric mice with humanized liver

Kazumi Sugihara, Tae Inoue, Kayoko Nitta, Shigeyuki Kitamura, Toru Hor ...

Session ID: 30S7B-4
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.163.1

CONFERENCE PROCEEDINGS FREE ACCESS

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GENERAL PREDICTION OF DRUG-DRUG INTERACTIONS FROM INTERACTION WITH SELECTIVE INHIBITOR OR SUBSTRATE

Akihiro Hisaka, Yoshiyuki Ohno, Hiroshi Suzuki

Session ID: 30S7B-5
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.164.1

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Symposium 8
Epigenetics as a mechanism for regulating expression and function of enzymes and transporters

ALLELIC EXPRESSION IMBALANCE OF THE HUMAN CYP3A4 GENE AND ITS APPLICATION TO PHARMACOTHERAPY

Ichiro Ieiri, Takeshi Hirota, Kana Ohishi, Shun Higuchi

Session ID: 01S8A-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.168.1

CONFERENCE PROCEEDINGS FREE ACCESS

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ROLE OF HEPATOCYTE NUCLEAR FACTOR 1 AND DNA METHYLATION IN THE REGULATION OF XENOBIOTIC TRANSPORTERS

Ryota Kikuchi, Hiroyuki Kusuhara, Naka Hattori, Kunio Shiota, Insook K ...

Session ID: 01S8A-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.169.1

CONFERENCE PROCEEDINGS FREE ACCESS

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MOLECULAR MECHANISM OF ACTION OF NOVEL ANTITUMOR AGENTS THAT CAUSE EPIGENETIC CHANGES

Minoru Yoshida

Session ID: 01S8A-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.170.1

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Forum 2006
How should DMPK scientists collaborate with toxicologists?
-Drug metabolites study in humans-

Current Status and Future Aspect of Toxicological Safety Assessment in the Drug Discovery and Development

Ikuo Horii

Session ID: F-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.172.1

CONFERENCE PROCEEDINGS FREE ACCESS

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FDA'S CURRENT DRAFT GUIDANCE FOR SAFETY TESTING OF DRUG METABOLITES: JPMA'S VIEW AND PERSPECTIVES

Shinsaku Naito

Session ID: F-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.173.1

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PRECLINICAL SAFETY EVALUATIONS OF DRUG METABOLITES -CURRENT STANCE OF JAPANESE REGULATORIES-

Osamu Fueki

Session ID: F-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.174.1

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Preclinical study for drug metabolism and toxicity in a Japanese population

Hiroshi Yamazaki

Session ID: F-4
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.175.1

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From a standpoint of clinician: Expectation for application of molecular imaging in pharmacodynamic study

-comparison among biodistribution data in human and animals-

Tomio Inoue

Session ID: F-5
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.176.1

CONFERENCE PROCEEDINGS FREE ACCESS

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ROLE OF DRUG METABOLISM AND PHARMACOKINETICS STUDIES IN SAFETY TESTING OF DRUG METABOLITES

-IMPORTANCE OF RI STUDY ON JAPANESE SUBJECTS-

Toshihiko Ikeda

Session ID: F-6
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.177.1

CONFERENCE PROCEEDINGS FREE ACCESS

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Young Scientists' Symposium

Molecular mechanism of the nuclear receptors-mediated transcription

Junn Yanagisawa

Session ID: YS-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.180.1

CONFERENCE PROCEEDINGS FREE ACCESS

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RECENT PROGRESS IN NON-CODING RNA RESEARCH

Akio Kanai

Session ID: YS-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.181.1

CONFERENCE PROCEEDINGS FREE ACCESS

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INTRACELLULAR SORTING OF MEMBRANE AND SECRETORY PROTEINS RELATED TO DISEASES

Hirofumi Kai

Session ID: YS-3
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.182.1

CONFERENCE PROCEEDINGS FREE ACCESS

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LARGE-SCALE CHARACTERIZATION OF GLYCOPROTEINS

Hiroyuki Kaji, Toshiaki Isobe

Session ID: YS-4
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.183.1

CONFERENCE PROCEEDINGS FREE ACCESS

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Informatics Strategy for Chemical Genomic Drug Discovery

Yasushi Okuno

Session ID: YS-5
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.184.1

CONFERENCE PROCEEDINGS FREE ACCESS

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DRUG DISCOVERY AND HEPATOTOXICITY

Tamio Fukushima

Session ID: YS-6
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.185.1

CONFERENCE PROCEEDINGS FREE ACCESS

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Short Oral Presentations

CHANGES OF INTESTINAL AND HEPATIC CYP3A ACTIVITY AFTER ORAL ADMINISTRATION OF ENZYME INDUCER

Tatsuya Honjyo, Kazunori Iwanaga, Makoto Miyazaki, Masawo Kakemi

Session ID: 29C09-1
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0.192.1

CONFERENCE PROCEEDINGS FREE ACCESS

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MOLECULAR MECHANISM OF HUMAN CYP2A6 INDUCTION VIA PXR AND PGC1a

Eriko Higashi, Miki Nakajima, Masahiro Itoh, Ryoko Yoshida, Miki Katoh ...

Session ID: 29C09-2
Published: 2006
Released on J-STAGE: November 18, 2006

DOIhttps://doi.org/10.14896/jssxmeeting.21.0_192_2

CONFERENCE PROCEEDINGS FREE ACCESS

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