Annual Meeting of the Japanese Society of Toxicology

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33rd Annual Meeting of the Japanese Society of Toxicology

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Effects of NSG on rat cultured embryos.

Atsushi Yokoyama, Masaharu Akita, R.D. Fuss

Session ID: P-135
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.201.0

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Effects of MAMG on rat Cultured embryos.

Atsushi Yokoyama, Masaharu Akita, R.D. Fuss

Session ID: P-136
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.202.0

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Effects of TRK on rat cultured embryos.

Atsushi Yokoyama, Masaharu Akita, R.D. Fuss, Osamu Nishibe

Session ID: P-137
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.203.0

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Effects of ADK on rat cultured embryos.

Atsushi Yokoyama, Masaharu Akita, R.D. Fuss

Session ID: P-138
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.204.0

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Effects of polychlorinated biphenyls on cultured rat embryos

Masaharu Akita, Mari Kato, Atsushi Yokoyama, Kouichi Haraguchi, Nobuyu ...

Session ID: P-139
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.205.0

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Effect of Clofibrate on hepatic enzyme induction in juvenile rats

Yoshiji Asaoka, Rio Itamura, Masao Horimoto, Ikuo Horii

Session ID: P-140
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.206.0

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Effect of Phenobarbital on mRNA expression of hepatic cytochrome P450 in juvenile rats

Yoshiji Asaoka, Masanori Sakimura, Rio Itamura, Masao Horimoto, Ikuo H ...

Session ID: P-141
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.207.0

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Effect of phenobarbital on serum testosterone and LH concentration in juvenile rats

Rio Itamura, Yoshiji Asaoka, Masao Horimoto, Ikuo Horii

Session ID: P-142
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.208.0

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Postnatal developmental changes in testosterone and LH concentration in juvenile rats

Rio Itamura, Yoshiji Asaoka, Masao Horimoto, Ikuo Horii

Session ID: P-143
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.209.0

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Non-clinical juvenile animal studies for pediatric drugs (1) – Investigation of NDA documents and assessment reports in Japan –

Takashi Nagayama, Nobuyuki Baba, Hirohiko Goto, Tetsushi Dodo, Katsuyu ...

Session ID: P-144
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.210.0

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Non-clinical juvenile animal studies for pediatric drugs (2) – Questionnaire survey –

Tetsushi Dodo, Katsuyuki Nishiki, Kazuhiro Shimomura, Masao Horimoto, ...

Session ID: P-145
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.211.0

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Non-clinical juvenile animal studies for pediatric drugs (3) - A comparison between the FDA guidance and EMEA draft guideline -

Masao Horimoto, Kouji Koike, Toru Nawa, Tetsushi Dodo, Katsuyuki Nishi ...

Session ID: P-146
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.212.0

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Effects of 4-hydroxybenzophenone on the reproductive organs of suckling male rats

Kuniaki Tayama, Yoshio Nakagawa, Yoshimitsu Sakamoto, Hiroshi Ando, Yo ...

Session ID: P-225
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.291.0

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Preliminary Validation Studies on BCO-P

Eckhard Deparade, Ullmann Ludwig, Ullmann Lundwigh, Takayuki Anzai

Session ID: P-147
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.213.0

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Accumulation of chlorinated and brominated persistent toxic substances and their relationship to toxicological effects in wild rats in Japan

tomomi kamiya, takumi takasuga, tutomu tanikawa, mayumi isiduka, syoui ...

Session ID: P-148
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.214.0

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Time course of the changes in energy metabolism under fasted conditions in rats

Yukie Nakashita, Yoshinobu Ohkubo, Akira Horinouchi, Akemi Matsumoto, ...

Session ID: P-149
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.215.0

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Gene Expression Profile Analysis of T24 Human Bladder Cancer Cells

Tomoko Muto, Yoshikatsu Kanai, Shin Wakui, Hitoshi Endou

Session ID: P-150
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.216.0

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Positive ReinforcementTraining In Dogs And Primates Undergoing Regulatory Toxicity Studies

Springall Christophes J, Kelly Janet, Grainger S

Session ID: P-151
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.217.0

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Effort to Perform "Guidance for Animal Testings" in the JPMA members

Toshiaki Ochiai, Fujio Sekiguchi, Kazutaka Mitsui, Syunsuke Kuroiwa, T ...

Session ID: P-152
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.218.0

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Useful Toxicological Information for GHS Classification of Chemicals

Takeshi Morita, Susumu Ishimitsu, Yasushi Kojima, Shiho Sasaki, Kaoru ...

Session ID: P-153
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.219.0

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Second survey on serious adverse events in clinical pharmacology studies

Yasumoto Kikuchi, Ichiro Fukazawa, Hajime Iijima, Tsuyoshi Momma, Hiro ...

Session ID: P-154
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.220.0

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Nonclinica safety evaluation for the development of fixed combination drugs - A comparison between Japan, US and Europe -

Yoshimitsu Harada, Masayuki Omote

Session ID: P-155
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.221.0

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Non-clinical Safety Evaluation of Vaccine - Task Force of Guideline on Non-clinical Safety Studies of Vaccine, Non-Clinical Evaluation Subcommittee, Japan Pharmaceutical Manufacturers Association -

Hajime Matsui, Hideki Yamasaki, Yukio Fujimaki, Shoji Nakai, Takashi U ...

Session ID: P-156
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.222.0

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Nonclinical safety studies of anti-cancer agents: Results of questionnaire survey by JPMA.

Shuichi KAI, Shoji ASAKURA, Mutsumi SUZUKI, Tadashi FURUKAWA, Yuko MIY ...

Session ID: P-157
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.223.0

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Questionnaire Survey on Education of Non-Clinical Toxicologists(Part 1) : Present Status on Education of Pharmaceutical Companies in Japan -Education Task Force, Non-Clinical Evaluation Subcommittee, Drug Evaluation Committee, Japan Pharmaceutical Manufacturers Association-

Akitoshi ASAMI, Yasuyoshi AZUMA, Yusuke KAMITA, Shigeo KAWANO, Kaoru T ...

Session ID: P-158
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.224.0

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Questionnaire Survey on Education of Non-Clinical Toxicologist (Part 2): Training for Research Staff Conducting Toxicological Studies -Task Force on Education, Non-clinical Evaluation Subcommittee, Drug Evaluation Committee, Japan Pharmaceutical Manufacturers Association-

Kaoru TANIGUCHI, Yusuke KAMITA, Akitoshi ASAMI, Yasuyoshi AZUMA, Shige ...

Session ID: P-159
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.225.0

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Questionnaire Survey on Education of Non-Clinical Toxicologists (Part 3): Education for Comprehensive Risk Assessment -Education Task Force, Non-Clinical Evaluation Subcommittee, Drug Evaluation Committee, Japan Pharmaceutical Manufacturers Association-

Takashi HIRONAKA, Shigeo KAWANO, Akitoshi ASAMI, Yasuyoshi AZUMA, Yusu ...

Session ID: P-160
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.226.0

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Diagnostic specificity of cardiac troponin T measurements in evaluation of drug-induced cardiotoxicity in rats – investigation of relationship between murine progressive cardiomyopathy and cardiac troponin T measurements in SD rats –

Tadakazu TAKAHASHI, Toshiyuki SHODA, Yuji YAMAZAKI, Yuusuke SUZUKI, Sh ...

Session ID: P-161
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.227.0

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The Application of Cardiac Troponin I (cTnI) and T (cTnT) for Cardio Toxicity Assessment in Cynomolgus Monkeys.

Byong Lyul Lee, Richard Grant, Tim Dawe, Chad Greenfield, Keikou Okasa ...

Session ID: P-162
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.228.0

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Evaluation of glutamate dehydrogenase (GLDH) as a blood biomarker of hepatotoxicity in rats

Takeshi Iidaka, Rie Kikkawa, Masaaki Kurata

Session ID: P-163
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.229.0

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Plasma Flt3 ligand level as a predictive indicator of hematopoietic function in mice.

Akio KOBAYASHI, Yuusuke SUZUKI, Shin-ichi OSHIDA, Kazuma KONDO, Tadaka ...

Session ID: P-164
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.230.0

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The use of faecal corticosteriod levels as a stress marker in non-human primates (Macaca Fascicularis)

Christopher J Springall, Janet Kelly, M Campey

Session ID: P-165
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.231.0

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Immunohistochemical study on the distribution of adipophilin positive lipid droplets in rats

Toshifumi Tashiro, Shim-mo Hayashi, Ikuo Horii

Session ID: P-166
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.232.0

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Benzene induced hemopoietic toxicity is induced by possible stem-cell specific xenobiotic metabolism mediated by aryl hydrocarbon receptor in the bone marrow.

Yoko Hirabayashi, Byung-Il Yoon, Guang-Xun Li, Yoshiaki Fujii-Kuriyama ...

Session ID: P-167
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.233.0

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Inorganic arsenite alters macrophage generation from human pripheral blood monocytes

Teruaki Sakurai, Seiichiro Himeno

Session ID: P-168
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.234.0

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Toxic effects of chromated copper arsenate (CCA) used as a wood preservative on the hematopoietic system in rats

Sayuri KOJIMA, Junya SASAKI, Nobuaki NAKASIMA, Takanori HARADA

Session ID: P-169
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.235.0

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Strain, age and sex differences in bone marrow cytology in rats

Junya SASAKI, Sayuri KOJIMA, Nobuaki NAKASHIMA, Takanori HARADA

Session ID: P-170
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.236.0

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Rat bone marrow examination using flow cytometry: Investigation for two different methods of cell classification and simultaneous measurement for total nucleated cell counts

Masaaki Kurata, Takeshi Iidaka

Session ID: P-171
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.237.0

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Flow cytometric analysis of immunocytes and hematopoietic cells from rat thymus, spleen and bone marrow using a fluorescent stain for DNA

Masaaki Kurata

Session ID: P-172
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.238.0

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Comparison of Lymphocyte Gating in T-cell Subsets Analysis of Immunotoxicity Studies

Hiroko I, Yoko ISHIKAWA, Takayuki KUBOTA, Masanori SAKAGUCHI, Hiroyuki ...

Session ID: P-173
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.239.0

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Study on the Mechanism of Drug Allergy. Dansyl Chloride Glutathione S-Transferase Conjugate Associated with the Allergic Reaction.

Hidenari Shigematsu, Hiroshi Saito, Naoto Uramaru, Tadashi Watabe

Session ID: P-174
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.240.0

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Vehicle effects on Murine Local Lymph Node Assay

Wang-Fan Weizheng, Eckhard Deparade, Ullmann Ludwig, Takayuki Anzai

Session ID: P-176
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.242.0

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Use of multiple measurements for Non-Radioisotopic Local Lymph Node Assay (Non-RI LLNA)

Tomoki Fukuyama, Yukari Tajima, Koichi Hayashi, Atsuko Haishima, Hidea ...

Session ID: P-177
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.243.0

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Comparison of non-radioisotopic endopoins in the local lymph node assay

Yoshiaki Ikarashi, Li Liu, Masa-aki Kaniwa, Toshie Tsuchiya

Session ID: P-178
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.244.0

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Maintenance of hepatocyte differentiation in vitro - Effect of Culture conditions

Declan Mulhern, Shinya Yokokawa, Shinichiro Nagatsuka, Yasuhisa Adachi ...

Session ID: P-179
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.245.0

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Development of a new three-dimensional culture of human hepatocytes

TATSUYA YAMAGUCHI, TAKUYA ISHIBASHI, KOUJI NAKAZAWA, HIROSHI MIZUMOTO, ...

Session ID: P-180
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.246.0

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Evaluation of the species differences in response to PPAR agonists using primary cultured hepatocyte from rat, mouse, dog and monkey

Kazunori Fujimoto, Kazumi Ito, Hiroyuki Kishino, Kyoko Watanabe, Miyuk ...

Session ID: P-181
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.247.0

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Involvement of transporters in the hepatic uptake and biliary excretion of telmisartan and its glucuronide, a selective antagonist of the angiotensin II AT1-receptor, in humans

Naoki Ishiguro, Kazuya Maeda, Takashi Igarashi, Yuichi Sugiyama

Session ID: P-182
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.248.0

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Efficiency of toxicological screening at drug-discovery stage (3) Effect of seeding cell number and washing time on HTS-phospholipidosis assay

Toshihiko Kasahara, Keisuke Tsubakimoto, Makoto Miyauchi, Takuo Ogihar ...

Session ID: P-183
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.249.0

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Physicochemical and cell-based approach for early screening of phospholipidosis-inducing potential

Kaori Tomizawa, Kiyohiko Sugano, Hiroshi Yamada, Ikuo Horii

Session ID: P-184
Published: 2006
Released on J-STAGE: June 23, 2006

DOIhttps://doi.org/10.14869/toxp.33.0.250.0

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