Annual Meeting of the Japanese Society of Toxicology

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The 35th Annual Meeting of the Japanese Society of Toxicology

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Plenary Lecture

Plenary Lecture 1

Scientific Basis for Risk Analysis Applied to Food-Related Substances - From a viewpoint of regulatory science -

Yuzo Hayashi

Session ID: PL-1
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.1.0

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Plenary Lecture 2

Comparative Juvenile Safety Testing of New Therapeutic Candidates: Relevance of Laboratory Animal Data for Children.

Timothy D Anderson, K. Nasir Khan, Mark E Hurtt

Session ID: PL-2
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.2.0

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Plenary Lecture 3

Toxicological Mechanisms and Actions of Nuclear Receptor During Early Development

Kenneth S. Korach, John F. Couse, Sylvia Curtis-Hewitt, Vickie R. Walk ...

Session ID: PL-3
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.3.0

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Symposium on Children's Toxicology

Symposium on Children's Toxicology 1

Basic and Clinical Aspects of Liver Injury in Children and Fetuses

Toxicity of 5-FU for pyrimidine metabolic disorders, and that of pivalic acid for carnitine metabolism.

Tetsuya Ito

Session ID: CS1-1
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.4.0

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Mechanism of anti-oxidant therapy in liver diseases

Kimitaka Takitani

Session ID: CS1-2
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.5.0

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Relationship between oxidative stress and anti-oxidant systems in liver of patients with Wilson disease and Idiopathic Copper Toxicosis: hepatic manifestation in Copper Accumulation as a consequence of augmented oxidative stress

Hironori Nagasaka

Session ID: CS1-3
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.6.0

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Mitochondrial respiratory chain disorder and liver disease in children

Kei Murayama

Session ID: CS1-4
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.7.0

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Symposium on Children's Toxicology 2

Basic and Clinical Aspects of Drug-induced Renal Injury in Children and Fetuses

Clinical and pathological features of ACEI/ARB fetopathy: significance of aldosterone effect on fetal kidney

Takashi Sekine, Takashi Igarashi

Session ID: CS2-1
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.8.0

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Nephtotoxicity induced by anti-cancer drug in children

Mikiya Fujieda, Akira Matsunaga, Takashi Sekine

Session ID: CS2-2
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.9.0

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Significance of drug transporters in the development of renal toxicity

Takashi Sekine

Session ID: CS2-3
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.10.0

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Non-clinical study on nephrotoxicity in fetus and infant

Masami Suzuki

Session ID: CS2-4
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.11.0

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Symposium on Children's Toxicology 3

How the environment and genetics influence the development of children

Disorders of brain development induced by prenatal alcohol intake

Yoshihiro Fukui

Session ID: CS3-1
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.12.0

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Impairment of brain development and behavioral disturbance induced by prenatal exposure of domoic acid

Kentaro Tanemura, Katsuhide Igarashi, Ken-ichi Aisaki, Satoshi Kitajim ...

Session ID: CS3-2
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.13.0

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Assisted reproductive technologies and developmental abnormalities

Kohei Shiota, Shigehito Yamada

Session ID: CS3-3
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.14.0

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Investigating gene-to-behavior pathways in psychiatric disorders: the use of a comprehensive behavioral test battery on genetically engineered mice

Tsuyoshi Miyakawa

Session ID: CS3-4
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.15.0

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Symposium on Children's Toxicology 4

" What/how should we know the safety evidence from preclinical data before starting a pediatric clinical study ? "

Pharmacokinetics in children

Tsuyoshi YOKOI

Session ID: CS4-1
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.16.0

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Role of environment and immunity on the development of childhood allergic and immunologic disorders

Hirohisa Saito

Session ID: CS4-2
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.17.0

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Dynamic changes in early development of immune system in macaque monkeys.

Keiji Terao

Session ID: CS4-3
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.18.0

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Clinical Pediatric Safety Planning based on Preclinical Toxicity Studies and Pediatric Pharmacovigilance Guidance

Neha Sheth, Rachel Sobel, Gail Cawkwell

Session ID: CS4-4
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.19.0

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Symposium on Children's Toxicology 5

Children's Immunology, what can we learn from animal studies

Decidual cells induce the specific immune system of the feto-maternal interface

Orie Nakamura

Session ID: CS5-1
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.20.0

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Aging of Thymus Immunity

Yasuaki ARAKAWA

Session ID: CS5-2
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.21.0

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Effect of prenatal and postnatal exposure to low-level toluene on immune development in infant mice

SHOJI YAMAMOTO, HIDEKAZU FUJIMAKI

Session ID: CS5-3
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.22.0

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Breakdown of mucosal immunity in the gut and allergic sensitization

Sho Ishikawa

Session ID: CS5-4
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.23.0

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New Material Toxicology Symposium

New Material Toxicology Symposium 1

Coordination for safety assessment of new materials

Public Engagement on Nanotechnology in the world

Masahiro Takemura

Session ID: NS1-1
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.24.0

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Current approaches toward the safety of manufactured nanomaterials

Nobuhiro Yamamoto

Session ID: NS1-2
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.25.0

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AIST's activities and NEDO project on risk of manufactured nanomaterials

Masashi GAMO

Session ID: NS1-3
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.26.0

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Efforts by the NIHS to evaluate the health effects of manufactured nanomaterial

Akihiko Hirose

Session ID: NS1-4
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.27.0

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New Material Toxicology Symposium 2

Progress on the studies for Nanomaterial safety assessment

Studies for percutaneous exposure assessment of nanomaterials

Hiroshi Tokunaga, Tomoko Obama, Tadashi Uchino, Yoshiaki Ikarashi

Session ID: NS2-1
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.28.0

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Tissue reaction to nanoparticles and visualization of their internal diffusion

Fumio WATARI, Shigeaki Abe, Motohiro Uo, Mitsue Esaki, Manabu Morita, ...

Session ID: NS2-2
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.29.0

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Effects of intratracheally instilled carbon nanotubes on respiratory systems.

Akiko Furuyama

Session ID: NS2-3
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.30.0

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Proposal of a medium-term assay system for evaluation of the carcinogenicity of nanoparticles

Hiroyuki Tsuda, Jiegou Xu, Katsumi Fukamachi, Yoshiyuki Inoue, Mineo T ...

Session ID: NS2-4
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.31.0

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Intraperitoneal injection studies for the evaluation of nanomaterials

Atsuya Takagi, Akihiko Hirose

Session ID: NS2-5
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.32.0

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Symposium

Symposium 1

Toxicomics

Application of omics technologies for liver injury assessment in drug development

Takashi Yamoto, Yosuke Ando, Naoki Kiyosawa, Sunao Manabe

Session ID: S1-1
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.33.0

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Usability and its practical application of toxicogenomics for assessing drug-induced nephrotoxicity

Takeki Uehara, Toshiyuki Maruyama, Tatsuhiko Baba, Ikuo Kato

Session ID: S1-2
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.34.0

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Molecular Toxicology Enhancement by the Percellome Project

Jun Kanno

Session ID: S1-3
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.35.0

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Systems Biology Approach to Toxicomics

Hiroaki Kitano

Session ID: S1-4
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.36.0

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Symposium 2

Risk assessment/Risk prediction and Regulatory Science

Risk Assessment and Hazard Assessment for Risk Trade-off Analysis

Masashi GAMO

Session ID: S2-1
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.37.0

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Factors determining susceptibility from exposure to environmental chemicals

HIDEKAZU FUJIMAKI

Session ID: S2-2
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.38.0

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High-Resolution toxicology by Toxicogenomics

Satoshi Kitajima, Jun Kanno

Session ID: S2-3
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.39.0

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Symposium 3

Fetal Basis for Adult Disease

Organotins are potent inducers of vertebrate adipogenesis: the case for obesogens

Bruce Blumberg, Taisen Iguchi, Hajime Watanabe, Jun Kanno, Felix Gruen

Session ID: S3-1
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.40.0

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Effect of valproic acid on neural stem cell differentiation

Masahiko Abematsu, Jenny Hsieh, Fred H. Gage, Kenji Kohno, Kinichi Nak ...

Session ID: S3-2
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.41.0

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Change of DNA methylation status by dioxin exposure during fetal stage

Seiichiroh Ohsako, Etsuko Sugai, Yoshinori Sakata, Kana Matsuda, Watar ...

Session ID: S3-3
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.42.0

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Epigenetic influence of estrogen caused by neonatal exposure

Hajime WATANABE

Session ID: S3-4
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.43.0

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Workshop

Workshop 1

Safety Assessment of Nucleic acid Medicine

Quaility and safety of nucleotide products and its update

Teruhide Yamaguchi, Eriko Uchida

Session ID: W1-1
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.44.0

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Current issues of nonclinical safety studies

Akio Ohtani

Session ID: W1-2
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.45.0

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Case Studies of Antisense

Scott Henry

Session ID: W1-3
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.46.0

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Progress and challenges in the development of RNA therapeutics

Jun-ichi Yano

Session ID: W1-4
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.47.0

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Workshop 2

Challenges for infant drug development

Physical Development and Associated Changes in Pharmacokinetics and Dynamics in Children

Hirotoshi Echizen

Session ID: W2-1
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.48.0

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Current Status of Pediatric Clinical Trials in Japan

Hidefumi Nakamura

Session ID: W2-2
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.49.0

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Juvenile animal study guideline

Kazuhiro SHIMOMURA

Session ID: W2-3
Published: 2008
Released on J-STAGE: June 25, 2008

DOIhttps://doi.org/10.14869/toxp.35.0.50.0

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