The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
LEUHISTIN, A NEW INHIBITOR OF AMINOPEPTIDASE M, PRODUCED BY Bacillus laterosporus BMI156-14F1
II. STRUCTURE DETERMINATION OF LEUHISTIN
SHIGEMI YOSHIDA, HIROSHI NAGANAWA, TAKAAKI AOYAGI, TOMIO TAKEUCHI, YASUO TAKEUCHI, YOSHIO KODAMA
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1991 Volume 44 Issue 6 Pages 579-581

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Abstract

Leuhistin, a new inhibitor of aminopeptidase M, has been isolated from the culture broth of Bacillus laterosporus BMI156-14F1. The structure of leuhistin was determined by NMR studies. X-Ray and chemical analysis confirmed the absolute structure to be (2R, 3S)-3-amino-2-hydroxy-2-(1H-imidazol-4-ylmethyl)-5-methylhexanoic acid.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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