A Nitro Analogue of Staurosporine and Other Minor Metabolites Produced by a Streptomyces longisporoflavus Strain

YANG CAI; ANDREAS FREDENHAGEN; PAUL HUG; HEINRICH H. PETER

doi:10.7164/antibiotics.48.143

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

A Nitro Analogue of Staurosporine and Other Minor Metabolites Produced by a Streptomyces longisporoflavus Strain

YANG CAI, ANDREAS FREDENHAGEN, PAUL HUG, HEINRICH H. PETER

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JOURNAL FREE ACCESS

1995 Volume 48 Issue 2 Pages 143-148

DOI https://doi.org/10.7164/antibiotics.48.143

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Abstract

From the staurosporine-producing strain Streptomyces longisporoflavus R-19 various minor metabolites were isolated: They include a new compound with a nitro function in C-4' and other metabolites related to Staurosporine. The new structures were elucidated by spectroscopic methods, mainly ¹H NMR and ¹³C NMR and by comparison with TAN-1030A. The new compounds inhibited protein kinase C with IC₅₀ values in the nanomolar range.

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