New Antitumor Substances, FR901463, FR901464 and FR901465 I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities

HIDENORI NAKAJIMA; BUNJI SATO; TAKASHI FUJITA; SHIGEHIRO TAKASE; HIROSHI TERANO; MASAKUNI OKUHARA

doi:10.7164/antibiotics.49.1196

New Antitumor Substances, FR901463, FR901464 and FR901465

I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities

HIDENORI NAKAJIMA, BUNJI SATO, TAKASHI FUJITA, SHIGEHIRO TAKASE, HIROSHI TERANO, MASAKUNI OKUHARA

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JOURNAL FREE ACCESS

1996 Volume 49 Issue 12 Pages 1196-1203

DOI https://doi.org/10.7164/antibiotics.49.1196

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Abstract

New antitumor substances, FR901463, FR901464 and FR901465 were isolated from the culture broth of a bacterium of Pseudomonas sp. No.2663.
FR901463, FR901464 and FR901465 remarkably enhanced the transcriptional activity of the promoter of SV40 DNA virus. Further, these compounds exhibited potent anti tumor activities against murine and human tumor cell lines in vitro.

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