The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
BE-31405, a New Antifungal Antibiotic Produced by Penicillium minioluteum
I. Description of Producing Organism, Fermentation, Isolation, Physico-chemical and Biological Properties
HIROMASA OKADA, SEIGO KAMIYA, YASUKO SHIINA, HIROAKI SUWA, MASAO NAGASHIMA, SHIGERU NAKAJIMA, HARUKI SHIMOKAWA, EIJI SUGIYAMA, HISAO KONDO, KATSUHISA KOJIRI, HIROYUKI SUDA
Author information
JOURNAL FREE ACCESS

1998 Volume 51 Issue 12 Pages 1081-1086

Details
Abstract

A new antifungal antibiotic, BE-31405, was isolated from the culture broth of a fungal strain, Penicillium minioluteum F31405. BE-31405 was isolated by adsorption on high porous polymer resin (Diaion HP-20), followed by solvent extraction, precipitation and crystallization. BE-31405 showed potent growth inhibitory activity against pathogenic fungal strains such as Candida albicans, Candida glabrata and Cryptococcus neoformans, but did not show cytotoxic activity against mammalian cells such as P388 mouse leukemia. The mechanism studies indicated that BE-31405 inhibited the protein synthesis of C. albicans but not of mammalian cells.

Content from these authors
© Japan Antibiotics Research Association
Previous article Next article
Favorites & Alerts

Recently viewed articles
Predecessor

The Journal of Antibiotics, Series A

Share this page
feedback
 Top