New Derivatives of Tylosin: Chemical and Electrochemical Oxidation Products of Desmycosin
2002 Volume 55 Issue 9 Pages 807-813
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2002 Volume 55 Issue 9 Pages 807-813
Chemical and electrochemical oxidation of dienonic moiety of desmycosin were carried out. Successive chemical oxidation of desmycosin with m-chloroperbenzoic acid afforded a family of 12, 13-dihydro-12, 13-dehydroxy derivatives. Indirect electrochemical oxidation via hypobromite as an intermediate gave rise to the new bicyclo derivative of desmycosin, 13-hydroxy-3-dehydroxy-3, 12-oxa-desmycosin.
