Epsin N-terminal homology (ENTH) domains are present at the N-terminus of either the epsin or epsin-related (epsinR) proteins. These proteins have been involved in clathrin-mediated trafficking and are critical for membrane deformation at the site of vesicle budding. While more than one type of these proteins have been described in many eukaryotic cells, the protozoa parasite Giardia lamblia contains only one member of this ENTH-protein family. In the last two years, four works have been published showing that this giardial protein might play diverse functions. This commentary gives a brief overview on the current status of the particular characteristics and functions of this unique protein