Regenerative medicine is a new and promising medicine by making use of the natural healing potential of body itself for tissue regeneration and repairing. The healing potential is based on the inherent ability of cells for proliferation and differentiation. Regenerative medicine composes of regenerative therapy and regenerative research (cell research and drug discovery) which scientifically supports the future regenerative therapy. To realize regenerative medicine, DDS technology should be used to artificially create a local environment which can enhance the cell ability for tissue regeneration. Controlled release technology for biological factors with or without the combination of cells or their scaffold efficiently activates the cells ability in vivo, resulting in the cell-based natural induction of tissue regeneration. In addition, the DDS technology is indispensable for the further development of regenerative research. This paper overviews DDS technology applicable to regenerative medicine considering the scientific and practical definition of DDS.