Bacteria living in a biofilm can have significantly different properties from free-floating bacteria, as the dense and protected environment of the film allows them to cooperate and interact in various ways. This environment provides the resistance to detergents and antibiotics, as the dense extracellular matrix and the outer layer of cells protect the interior of the community. These biofilms cause the intractable infections. Therefore, the development of antibacterial drug delivery systems against the biofilm infection disease is strongly desired. In this review, we intended to design the surface modified PLGA nanoparticle and polymeric micelles for antibacterial drug delivery to the microorganisms in the biofilm. Clarithromycin-loaded drug carrier showed the stronger antibacterial effect against biofilm formed microorganisms compared with drug solution. Especially, CS-modified carrier indicated the more effective antibacterial activity and decreased the biofilm formation because nanocarrier adsorbed on the biofilm. Especially, soluplus micelles indicated the strongest anti-bacterial effect because the adsorption amount was higher than PLGA NP. Therefore, soluplus micelles with smaller particle size could access to the deeply part of biofilm which has sponge like structure.