Association between Preheparin Serum Lipoprotein Lipase Mass and Acute Myocardial Infarction in Japanese Men

Takashi Hitsumoto; Kunio Yoshinaga; Kaneyuki Aoyagi; Takeshi Sakurai; Masahito Kanai; Takashi Uchi; Hirofumi Noike; Hidefumi Ohsawa; Hitoshi Watanabe; Kohji Shirai

doi:10.5551/jat.9.163

Original Articles

Association between Preheparin Serum Lipoprotein Lipase Mass and Acute Myocardial Infarction in Japanese Men

Takashi Hitsumoto, Kunio Yoshinaga, Kaneyuki Aoyagi, Takeshi Sakurai, Masahito Kanai, Takashi Uchi, Hirofumi Noike, Hidefumi Ohsawa, Hitoshi Watanabe, Kohji Shirai

Author information

Takashi Hitsumoto
Cardiovascular Center, Sakura Hospital, School of Medicine, Toho University
Kunio Yoshinaga
Cardiovascular Center, Sakura Hospital, School of Medicine, Toho University
Kaneyuki Aoyagi
Cardiovascular Center, Sakura Hospital, School of Medicine, Toho University
Takeshi Sakurai
Cardiovascular Center, Sakura Hospital, School of Medicine, Toho University
Masahito Kanai
Cardiovascular Center, Sakura Hospital, School of Medicine, Toho University
Takashi Uchi
Cardiovascular Center, Sakura Hospital, School of Medicine, Toho University
Hirofumi Noike
Cardiovascular Center, Sakura Hospital, School of Medicine, Toho University
Hidefumi Ohsawa
Cardiovascular Center, Sakura Hospital, School of Medicine, Toho University
Hitoshi Watanabe
Clinical Laboratory Medicine, Sakura Hospital, School of Medicine, Toho University
Kohji Shirai
Clinical Laboratory Medicine, Sakura Hospital, School of Medicine, Toho University

Keywords: Preheparin serum lipoprotein lipase mass, Lipoprotein lipase activity, Coronary risk factor, Acute myocardial infarction

JOURNAL OPEN ACCESS

2002 Volume 9 Issue 4 Pages 163-169

DOI https://doi.org/10.5551/jat.9.163

Details

Abstract

A sensitive immunoassay system using a specific monoclonal antibody against lipoprotein lipase (LPL) recently demonstrated the presence of an LPL mass in preheparin serum. We reported that a preheparin serum LPL mass (pre-LPL mass) reflected the level of functioning LPL activity in the whole body and could be deeply involved in the progression of coronary atherosclerosis of stable organic angina pectoris. We examined the relation between the pre-LPL mass and acute myocardial infarction (AMI). We studied 44 males with AMI (AMI group) and 16 males with a normal coronary artery (NCA group), and measured the pre-LPL mass by enzyme-linked immunosorbent assay. Coronary risk factors including the pre-LPL mass were compared between the two groups and multiple regression analysis was performed for AMI. There were no significant differences in the lipid data, but the pre-LPL mass level was significantly low in the AMI group (52±16 vs 41±14 ng/ml, p=0.01), and a low pre-LPL mass concentration was observed in the small sized LDL group and/or the Midband positive group. Multiple regression analysis revealed that a low pre-LPL mass and hypertriglyceridemia were independent risk factors for AMI (t value=2.1, 2.4). The result indicates that a low pre-LPL mass may be an important risk factor for AMI and stable organic angina pectoris.

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