Decrease in the Kainate-Induced Wet Dog Shake Behavior in Genetically Epilepsy-Prone Rats: Possible Involvement of an Impaired Synaptic Transmission to the 5-HT2A Receptor

Eun-Joo Shin; Ji Hoon Jeong; Yoon Hee Chung; Tae-Woo Kim; Chan Young Shin; Won-Ki Kim; Kwang-Ho Ko; Hyoung-Chun Kim

doi:10.1254/jphs.09015SC

Short Communications

Decrease in the Kainate-Induced Wet Dog Shake Behavior in Genetically Epilepsy-Prone Rats: Possible Involvement of an Impaired Synaptic Transmission to the 5-HT_2A Receptor

Eun-Joo Shin, Ji Hoon Jeong, Yoon Hee Chung, Tae-Woo Kim, Chan Young Shin, Won-Ki Kim, Kwang-Ho Ko, Hyoung-Chun Kim

Author information

Eun-Joo Shin
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Korea
Ji Hoon Jeong
Department of Pharmacology, College of Medicine, Chung-Ang University, Korea
Yoon Hee Chung
Department of Anatomy, College of Medicine, Chung-Ang University, Korea
Tae-Woo Kim
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Korea
Chan Young Shin
Department of Pharmacology, School of Medicine, Konkuk University, Korea
Won-Ki Kim
Department of Neuroscience, School of Medicine, Korea University, Korea
Kwang-Ho Ko
Department of Pharmacology, College of Pharmacy, Seoul National University, Korea
Hyoung-Chun Kim
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Korea

Keywords: kainic acid, genetically epilepsy-prone rat, wet dog shake

JOURNAL FREE ACCESS

2009 Volume 110 Issue 3 Pages 401-404

DOI https://doi.org/10.1254/jphs.09015SC

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Abstract

Genetically epilepsy-prone rats (GEPR-9s) were derived from Sprague–Dawley rats (SD). The number of kainate-induced wet dog shake behavior (WDS) responses was found to decrease significantly in GEPR-9s compared to SD. WDS responses were potentiated by 5-hydroxytryptophan or 2,5-dimethoxy-4-iodoamphetamine and antagonized by ritanserin. The antagonizing effect of ritanserin on WDS latency was more evident in GEPR-9s than in SD, and hippocampal expression of activity-regulated cytoskeleton-associated protein paralleled the severity of WDS. The results suggest that downstream serotonergic synaptic activation is less pronounced in GEPR-9s than in SD and that the serotonergic agent may directly activate postsynaptic 5-HT2A receptors in both strains.

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