Conversion of 3H-Nitrendipine Binding to the Low Affinity Binding State Following the Treatment of Hippocampal Slices with Morphine

Tetsuo Ohnishi; Kihachi Saito; Sadaaki Maeda; Ken Matsumoto; Masayoshi Sakuda; Reizo Inoki

doi:10.1254/jjp.57.251

Conversion of ³H-Nitrendipine Binding to the Low Affinity Binding State Following the Treatment of Hippocampal Slices with Morphine

Tetsuo Ohnishi, Kihachi Saito, Sadaaki Maeda, Ken Matsumoto, Masayoshi Sakuda, Reizo Inoki

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JOURNAL FREE ACCESS

1991 Volume 57 Issue 2 Pages 251-254

DOI https://doi.org/10.1254/jjp.57.251

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Abstract

The effect of morphine on the binding of ³H-nitrendipine was studied in rat hippocampal preparations. Treatment of slices with morphine followed by the preparation of membrane fractions revealed the presence of low affinity binding sites. The effect of morphine was antagonized by naloxone. The effect was not observed when the membrane fraction was incubated with morphine. These results suggest that morphine changes the affinity of calcium for its channels and reduces its influx.

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