As the Doha Round of WTO negotiations continue to stagnate, moves toward mega-FTAs are accelerating around the world. The best way of improving the business environment for companies, which contributes to smoother global supply chains, is to establish global trade rules for the 21st century. It is essential for Japan to take the initiative in establishing global trade rules through mega-FTAs such as TPP, RCEP, and Japan-EU FTA so that Japanese companies can display their strengths. This paper argues the future of the global trade regime and Japan’s trade strategy in the light of the ongoing negotiations for mega-FTAs.