Abstract
The 2010 laboratory animal use statistics for Great Britain revealed that just over 3.7 million scientific procedures using animals were commenced, representing an increase of 3% (105,000) over the previous year. Laboratory animal numbers have steadily risen across the preceding decade, largely due to increasing use of genetically altered animals. However, their use has disturbing implications for animal welfare. Similar concerns are raised by increasing use of non-human primates, and of procedures conducted without any form of anaesthesia.