Abstract
Granulysin is a recently characterized cytotoxic granule expressed in cytotoxic T cells and NK cells. Although its cytotoxic effect against a number of tumor cell lines has been demonstrated in vitro, recent study with transgenic mice, and a number of clinical studies, have further established its significance in cancer immunology. Granulysin may offer a useful indicator in the prognosis of cancer, and an understanding of the mechanism by which it destroys target cells would provide vital information in the development of new therapies for the treatment of this disease.
