Annals of Cancer Research and Therapy
Online ISSN : 1880-5469
Print ISSN : 1344-6835
ISSN-L : 1344-6835
Circulating galectin-3 correlates with angiogenetic factors and indicators of systemic inflammation in patients with stage IV esophageal cancer
Tatsuo ShimuraMasahiko ShibataKenji GondaTakahiro NakajimaShun ChidaMasaru NodaSatoshi SuzukiIzumi NakamuraShinji OhkiSeiichi Takenoshita
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2016 Volume 24 Issue 1 Pages 30-34


Background and Aims: The significance of circulating galectin-3 in esophageal cancer has not yet been elucidated. The aim of this study was to identify the relationships between circulating galectin-3 and angiogenetic, nutritional, and inflammatory factors in patients with stage IV esophageal cancer.
Materials and Methods: We investigated the relationships between the level of circulating galectin-3 and angiogenetic factors, such as interleukin (IL)-6, vascular endothelial growth factor (VEGF), granulocyte colony-stimulating factor (G-CSF), and soluble intercellular adhesion molecule-1 (sICAM-1), and nutritional and inflammatory indicators in 11 patients with stage IV esophageal cancer.
Results: The concentration of galectin-3 in patients with stage IV esophageal cancer was significantly higher than in healthy volunteers. The amount of circulating galectin-3 correlated with the amount of serum IL-6 (r = 0.636, P < 0.05), VEGF (r = 0.721, P < 0.05), sICAM-1 (r = 0.745, P < 0.01), and C-reactive protein (r = 0.786, P < 0.05), as well as the lymphocyte count (r = −0.718, P < 0.05), and the neutrophil / lymphocyte ratio (r = 0.718, P < 0.05).
Conclusions: Galectin-3 may play a key role in progression of tumors by increasing the production of angiogenetic factors, leading to malnutrition by persistent systemic inflammation.

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© 2016 by The Japanese Society of Strategies for Cancer Research and Therapy
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