2018 Volume 26 Issue 2 Pages 116-119
Introduction: As patients with metastatic colorectal cancer (mCRC) have various clinical backgrounds and the treatment strategies that are applied in their management are diverse, it is difficult to accurately estimate their prognosis. We conducted this study to establish a prognostic nomogram for mCRC patients using a population-based database.
Materials and Methods: In this population-based, multicenter, retrospective, observational cohort study, we aimed to enroll 1,500 patients from all nine designated cancer hospitals across Fukushima prefecture from January 2008 to December 2015. Patients with a metastatic lesion according to the TNM classification (AJCC/TNM 8th) were eligible for inclusion. The primary outcome was overall survival. The last day of follow-up was December 31, 2017. We investigated the clinical significance of the following variables: age, sex, body mass index, Charlson comorbidity index, activities of daily living, location of colorectal cancer, degree of differentiation, TNM stage, number of distal metastatic organs, severity of each metastatic organ, symptoms from the primary lesion, laboratory markers, and method of treatment.
Discussion: This is the first prognostic nomogram of patients with mCRC created from a population-based cohort.
Trial registration: UMIN000033718 (registration date: 30/08/2018)
