Susd2/SUSD2, a putative tumor suppressor gene, inhibits growth of colorectal cancer cells

Abstract

We constructed inducible expression system of Susd2 gene which we previously identified as a novel tumor suppressor gene. Here we report the growth inhibition of colorectal cancer HCT116 cells and fibrosarcoma HT1080 cells by inducible expression of Susd2 protein from HCT/G5Susd2 and HT/G5Susd2 cells by infection of Ad/G4VP2, as revealed by colony formation and growth behavior. Thus, we found that Susd2 inhibits growth of cancer cells and this information may benefit to patients with malignant diseases.