2025 Volume 33 Issue 1 Pages 1-4
Introduction: This study investigates the BRAF mutations as a biomarker for colorectal cancer (CRC) in Moroccan population. Given limited data on BRAF, particularly in low- and middle-income countries, the study aims to address this lack of epidemiological data by carefully examining its frequency and correlations with clinicopathological features in Moroccan CRC patients. The research contributes to providing insights to enhance diagnostic and therapeutic strategies.
Methods: Archived FFPE tissue samples from Moroccan colorectal cancer patients, collected between January 1st, 2020, and December 31st, 2023, at the National Institute of Oncology in Rabat, Pathology Department, were analyzed using the Biocartis Idylla™ platform. Real-time PCR was employed for the qualitative detection of BRAF mutations.
Results: 320 tumors were enrolled for this study. BRAF mutations particularly V600E were found in 8.2% of cases, a statistical correlation was found between BRAF mutation and primary tumor site, as well as with the histological type. While no clear associations were found with gender, age, or degree of differentiation.
Conclusion: This work demonstrates that countries with low or middle incomes are capable of performing high-quality testing, significantly contributing to scientific progress in Africa and providing important information to the worldwide cancer research community.
