1994 Volume 3 Issue 1 Pages 31-34,6
A 68-year-old Japanese woman with locally recurrent gastric adenocarcinoma was treated by FLP (cisplatin, 5FU, and leucovorin) therapy.
On March 8, 1990, she underwent total gastrectomy for gastric adenocarcinoma, which was stage II (N1 S1 P0 H0) by the Japanese classification and Stage II (T2 N1 M0) by the American classification. She was given 5FU (150mg/day). Postoperarively, in May 1992, she complained of food sticking in her epigastrium. On June 29, fiberscopic examination revealed an ulcer opposite the jejunal anastomosis as well as stenosis. Biopsy of the jejunal mucosa showed group V changes. On August 11, she was admitted to our center with locally recurrent gastric adenocacinoma and impared food intake. She received parenteral nutrition and gradually improved. In September, she received intravenous FLP therapy twice.
During this therapy, transient nausea and diarrhea developed. Fiberscopic examination was performed twice after the completion of treatment and revealed healing of the ulcer to a scar with stenosis. Biopsy of the jejunl mucosa showed no malignancy. The patient underwent operation and no malignancy was detected, suggesting that the recurrent, tumor was cured.
