Abstract
A 54-year-old woman was referred to our hospital with well differentiated adenocarcinoma of the left lung and multiple metastases to both lungs. On November 7, 1991, chemotherapy with cisplatin, vindesine, and adriamycin was started. After two courses, the metastatic lesions showed complete disappearance, while the primary tumor showed a partial response. On January 13, 1992, partial resection of the left upper lobe was performed to remove the residual primary tumor. Histologic examination of the resected specimen demonstrated degenerative carcinoma. After surgery, five more courses of chemotherapy were given. On February 2, 1993, magnetic resonance imaging of the brain showed multiple metastases. The same chemotherapy was given again and complete disappearance of the brain metastases was noted after two courses. Four additional courses of chemotherapy with cisplatin and vindesine were given. In January 1994, she had a relapse of brain metastases. Three courses of chemotherapy were given, but the metastases showed no response. Thus, more than three years after the initiation of chemotherapy, the patient is alive with brain metastases and there has been no relapse of the lung tumor.
