Abstract
Kawasaki disease (KD) is a systemic vasculitis that affects mainly children under 5 years of age. Although over 50 years have passed since Dr. Tomisaku Kawasaki first reported KD, its cause remains unclear. We have been performing a histopathological study on vasculitis of KD. In addition, we established a murine model of systemic arteritis by injecting a Candida albicans cell wall polysaccharide. The arteritis that develops in the model shows a predilection for manifesting in the coronary artery and aortic root. Careful observation of human and experimental model is important to understand the pathogenesis of the vasculitis of KD.
