Abstract
Fatty acid remodeling systems for glycerophospholipids including acyl-CoA:lysophospholipid acyltransferases, and CoA-dependent or CoA-independent transacylation reactions are involved in the biosynthesis of the molecular species with different fatty acyl moieties and incorporation of arachidonic acid into phospholipids. Although various kind of acyltransferases have been cloned and characterized, the molecular mechanism of CoA-dependent or CoA-independent transacylation reactions has not been elucidated yet. In this article, recent progresses in acyltransferase research including the identification of the enzyme’s genes are described. In addition, the mechanisms of CoA-dependent or independent transacylation reactions are discussed. I also refer to the biosynthesis of arachidonic acid-containing lipid mediators during the processes of fatty acid remodeling of phospholipids.
