Exploration of essential oils that suppress oxidative stress-induced skin disorder and their protective mechanisms

Abstract

The skin is composed of the epidermis (keratinocytes), dermis (fibroblasts), and subcutaneous tissue and protects internal organs and regulates body temperature. Melanocytes, which produce melanin, are localized in the basal layer of the epidermis. Exposure to ultraviolet (UV) radiation causes excessive melanin production as well as decreased collagen production in fibroblasts and skin damage (keratinocyte cell death). Repeated exposure to UV radiation results in accumulated skin damage, causing “photoaging,” which is characterized by freckles and wrinkles. This study aimed to conduct global screening to identify essential oils that can suppress oxidative stress-induced skin disorder. Lavender oil showed multiple protective effects, including keratinocyte protection and increased collagen production in fibroblasts. Moreover, inhibition of melanin production and increased collagen production in fibroblasts were observed for Jasmine Abs. Antioxidant effects might mediate these protective effects. Hence, further analysis is necessary to identify the essential oil that is superior in suppressing oxidative stress-induced skin disorder.