Abstract
Ventilatory and cardiovascular responses to isometric exercise, with special reference to hand-grip exercise, were reviewed. Blood flow through the forearm (FBF) during muscular contraction is dependent on relative strength to iMVC (maximum voluntary contraction), duration of exercise, and hand temperature. FBF could attain steady state during exercise with intensities less than 15% MVC. Heart rate (HR) starts to increase with a latency as short as 0.4 to 0.6 sec in conscious animals and men in response to voluntary as well as electrically induced isometric exercise. This response is vagally transmitted. The sympathetic nerves mediated HR response with a longer delay is also found. Cardiac contractility is augmented via sympathetic p-receptors during isometric exercise. W'ith aging, HR response tends to be intensified, whereas, stroke volume response tends to be depressed. Thus increased cardiac output is resulted in elevated arterial blood pressure. Total vascular resistance is reported to be unaltered, or to increase, despite of consistent increase in muscle sympathetic activities during the isometric exercise. Ventilation is augmented during exercise, but the pattern of its response is not in full agreement among investigators. The underlying mechanisms to elicit those responses are discussed.
